徐放性微粒子を含有する徐放性口腔内崩壊錠・ハルナールD錠の開発 Development of a Modified-Release Fast-Disintegrating Tablet (Harnal D) Containing Fine, Modified-Release Particles

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Harnal D is a fast-disintegrating tablet containing fine, modified-release (MR) particles. The dissolution-controlled film on the MR particles consisted of a mixture of water-soluble and -insoluble polymers, with a very smooth particle surface (as determined by SEM observation). During dissolution testing, very fine pores on the surface of the MR particles were formed, and the drug release rate was controlled through these pores. The dissolution-controlled film was usually damaged during the compression process, and thus the dissolution rate increased. However WOWTAB technology, which was applied to Harnal D, can be manufactured at a low compression pressure, thereby avoiding damage to the dissolution-controlled film. In fact, there was no difference in the dissolution rate between the MR particles and tablet.

収録刊行物

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    膜 33(2), 82-84, 2008-03-01 

    THE MEMBRANE SOCIETY OF JAPAN

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各種コード

  • NII論文ID(NAID)
    10021167343
  • NII書誌ID(NCID)
    AN0023215X
  • 本文言語コード
    JPN
  • 資料種別
    NOT
  • ISSN
    03851036
  • NDL 記事登録ID
    9437622
  • NDL 雑誌分類
    ZR2(科学技術--生物学--生化学)
  • NDL 請求記号
    Z18-1127
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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