中枢セロトニントランスポーターと抗うつ薬

• 酒井 規雄

  広島大学 大学院医歯薬学総合研究科　神経・精神薬理学

書誌事項

タイトル別名

• Antidepressants as a Target of Serotonin Transporter
• チュウスウ セロトニン トランスポーター ト コウウツヤク

抄録

Serotonin transporter (SERT), a member of Na+/Cl– - dependent transporter family, is predicted to be a protein with a twelve membrane-spanning structure, which terminates the serotonergic neural transmission by re-uptaking serotonin into pre-synapse. It has been well-known that SERT is a target of antidepressants and abusive drugs. Although the pathogenesis of depression and mechanism underlying antidepressants action remains unclear, recent accumulated evidences have revealed that antidepressants promote the regeneration of neurons, which was damaged by repeated stress and recurrences of depression. In addition, analysis of crystal structure of bacterial leucine transporter, a homologue of mammalian Na+/Cl– - dependent neurotransmitter transporter, provides us a new information concerning the interactions of tricyclic antidepressants with serotonin transporter.

収録刊行物

• 膜

  膜 33 (3), 94-101, 2008

  日本膜学会

キーワード

• serotonin transporter
• antidepressant
• neural regeneration

詳細情報

• CRID: 1390282681398202496
• NII論文ID: 10021167379
• NII書誌ID: AN0023215X
• DOI: 10.5360/membrane.33.94
• ISSN: 18846440
• ISSN: 03851036
• NDL書誌ID: 9525506
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9525506
• Web Site: https://www.jstage.jst.go.jp/article/membrane/33/3/33_94/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008227545
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可