中枢セロトニントランスポーターと抗うつ薬 Antidepressants as a Target of Serotonin Transporter

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著者

    • 酒井 規雄 SAKAI Norio
    • 広島大学 大学院医歯薬学総合研究科 神経・精神薬理学 Department of Molecular and Pharmacological Neurosciences Graduate School of Biomedical Sciences, Hiroshima University

抄録

Serotonin transporter (SERT), a member of Na+/Cl– - dependent transporter family, is predicted to be a protein with a twelve membrane-spanning structure, which terminates the serotonergic neural transmission by re-uptaking serotonin into pre-synapse. It has been well-known that SERT is a target of antidepressants and abusive drugs. Although the pathogenesis of depression and mechanism underlying antidepressants action remains unclear, recent accumulated evidences have revealed that antidepressants promote the regeneration of neurons, which was damaged by repeated stress and recurrences of depression. In addition, analysis of crystal structure of bacterial leucine transporter, a homologue of mammalian Na+/Cl– - dependent neurotransmitter transporter, provides us a new information concerning the interactions of tricyclic antidepressants with serotonin transporter.

収録刊行物

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    膜 33(3), 94-101, 2008-05-01 

    THE MEMBRANE SOCIETY OF JAPAN

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各種コード

  • NII論文ID(NAID)
    10021167379
  • NII書誌ID(NCID)
    AN0023215X
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    03851036
  • NDL 記事登録ID
    9525506
  • NDL 雑誌分類
    ZR2(科学技術--生物学--生化学)
  • NDL 請求記号
    Z18-1127
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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