不斉トリフルオロメチル化反応の開発 Recent Advances in Enantioselective Trifluoromethylation Reactions

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著者

    • 柴田 哲男 SHIBATA Norio
    • 名古屋工業大学大学院工学研究科 Department of Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology
    • 水田 賢志 MIZUTA Satoshi
    • 名古屋工業大学大学院工学研究科 Department of Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology
    • 融 健 TORU Takeshi
    • 名古屋工業大学大学院工学研究科 Department of Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology

抄録

Fluorinated organic compounds have received considerable attention because they possess unique properties such as greater stability, higher lipophilicity, high electronegativity, and water and oil repellency, which are potentially beneficial in terms of development of novel pharmaceuticals and advanced materials. Such extreme and bizarre behaviors of the fluoro-organic compounds however, often make the synthesis of them all the more complicated, especially, when the synthesis of target compounds requires an enantio-controlled methodology. Many strategies can be employed for introduction of asymmetry into organic molecules, the enantioselective fluorination and fluoromethylation reactions are especially attractive because non-fluorinated prochiral substrates can be directly transformed to chiral fluoro-organic compounds with controlled absolute configuration. Significant progress has been made in the development of asymmetric fluorination reactions in recent years; however, the direct enantioselective trifluoromethylation remains achallenge. In this article, we review the recent developments in the enantioselective trifluoromethylation reactions including nucleophilic, electrophillic and radical approaches. Although the emphasis of this report will be on the enantioselective trifluoromethylation reaction, as well as the less studied enantioselective difluoromethylation and monofluoromethylation reactions will also be covered.

収録刊行物

  • 有機合成化学協会誌 : JOURNAL OF Synthetic Organic Chemistry JAPAN  

    有機合成化学協会誌 : JOURNAL OF Synthetic Organic Chemistry JAPAN 66(3), 215-228, 2008-03-01 

    The Society of Synthetic Organic Chemistry, Japan

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各種コード

  • NII論文ID(NAID)
    10021174123
  • NII書誌ID(NCID)
    AN0024521X
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    00379980
  • NDL 記事登録ID
    9415381
  • NDL 雑誌分類
    ZP11(科学技術--化学・化学工業--有機化学・有機化学工業)
  • NDL 請求記号
    Z17-256
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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