ヘテロ二官能性ポリエチレングリコールの精密合成に基づいたpH応答性ナノゲル粒子の調製とがんのピンポイント診断・治療への応用 Preparation of pH-Responsive Nanogels Based on the Precise Synthesis of Heterotelechelic Poly(ethylene glycol)s for Pinpoint Cancer Diagnosis and Therapy

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著者

    • 大石 基 OISHI Motoi
    • 筑波大学大学院数理物質科学研究科物性・分子工学専攻 Graduate School of Pure and Applied Sciences, University of Tsukuba
    • 長崎 幸夫 NAGASAKI Yukio
    • 筑波大学大学院数理物質科学研究科物性・分子工学専攻 Graduate School of Pure and Applied Sciences, University of Tsukuba

抄録

We described here novel approach to the precise synthesis of the heterotelechelic PEG deriva-tives to prepare pH-responsive PEGylated nanogels for pinpoint cancer diagnosis and therapy. In particular, use of potassium 3, 3-diethoxy-1-propanolate as an initiator for the polymerization of ethylene oxide gave various heterotelechelic PEGs with well-defined structure, high yield, and high purity. The pH-responsive PEGylated nanogels composed of cross-linked poly[2-(N, N-diethylamino) ethyl methacrylate] (polyamine) core and PEG tethered chains bearing a functional group(acetal group or carboxylic acid group) as a platform moiety for the installation of ligand molecules were synthesized by emulsion polymerization of vinyl benzyl group-ended heterotelechelic PEG, amine monomer, and cross-linker. In addition, PEGylated nanogels show unique properties and functions in synchronizing with the reversible volume phase transition of the polyamine gel core in response to pH. We list some of the biomedical applications of the nanogels, including tumor-specific 19F MRI probes and tumor-specific drug delivery carriers.

収録刊行物

  • 有機合成化学協会誌 : JOURNAL OF Synthetic Organic Chemistry JAPAN  

    有機合成化学協会誌 : JOURNAL OF Synthetic Organic Chemistry JAPAN 66(5), 428-435, 2008-05-01 

    The Society of Synthetic Organic Chemistry, Japan

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各種コード

  • NII論文ID(NAID)
    10021174866
  • NII書誌ID(NCID)
    AN0024521X
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    00379980
  • NDL 記事登録ID
    9503834
  • NDL 雑誌分類
    ZP11(科学技術--化学・化学工業--有機化学・有機化学工業)
  • NDL 請求記号
    Z17-256
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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