有機金属求核剤の炭素-金属結合活性化を基盤とする酸・塩基複合触媒システムの開発 Development of High Efficient Acid-Base Combination Catalyses Based on Carbon-Metal Bonds Activation in Organometallic Reagents

この論文にアクセスする

この論文をさがす

著者

抄録

For synthesis of secondary and tertiary alcohols, practical carbon-carbon bond forming reactions between organometallic reagents and carbonyl compounds have been developed over a century since the discovery of Grignard reaction in 1900 . Traditional organometallic reagents (i.e. Li, Mg, Si, Cu, and Zn reagents) should involve some fundamental functions, such as alkylating reagents, Lewis acids, and Br.Onsted bases . Thus, in principle, the efficiency of the nucleophilic addition should significantly increase if a carbon-metal bond in organometallic reagents can be activated by Lewis base catalysts and the substrates can be activated by native Lewis acid function of organometallic reagents. We report here that the highly efficient catalytic carbon-carbon bond forming reactions via carbon-metal bond activation in organometallic reagents using simple metal salt catalysts. A variety of acid-base promoting catalytic reactions, such as Grignard reaction, organozinc addition, 1, 4-addition of organocopper reagents, trimethylsilylcyanation, and Mukaiyama aldol reaction, were achieved toward the efficient asymmetric catalyses .

収録刊行物

  • 有機合成化学協会誌 : JOURNAL OF Synthetic Organic Chemistry JAPAN  

    有機合成化学協会誌 : JOURNAL OF Synthetic Organic Chemistry JAPAN 66(6), 564-577, 2008-06-01 

    The Society of Synthetic Organic Chemistry, Japan

参考文献:  90件

参考文献を見るにはログインが必要です。ユーザIDをお持ちでない方は新規登録してください。

各種コード

  • NII論文ID(NAID)
    10021175387
  • NII書誌ID(NCID)
    AN0024521X
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    00379980
  • NDL 記事登録ID
    9545006
  • NDL 雑誌分類
    ZP11(科学技術--化学・化学工業--有機化学・有機化学工業)
  • NDL 請求記号
    Z17-256
  • データ提供元
    CJP書誌  NDL  J-STAGE 
ページトップへ