金属錯体による高エナンチオ選択的X-H(X = N,O)挿入反応 [in Japanese] Highly Enantioselective X-H (X = N,O) Insertion Reactions by Metal Complexes [in Japanese]
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The catalytic insertion of a-diazo compounds into C-H or X-H (X = heteroatom) bonds is a very powerful organic transformation, due to the potential in forming highly versatile building blocks. Remarkable advances have been made in the methodology for catalytic asymmetric diazo insertion into C-H bond, but only limited success has been achieved for asymmetric insertions into X-H bonds. Recently, high levels of enantiocontrol in the asymmetric X-H insertions have been achieved by the device of well-defined chiral Cu complexes. In this short review, several recent examples of catalytic asymmetric N-H and 0-H insertions are introduced.
- J. Synth. Org. Chem. Jpn.
J. Synth. Org. Chem. Jpn. 66(7), 714-715, 2008-07-01
The Society of Synthetic Organic Chemistry, Japan