ネオニコチノイド系殺虫剤ジノテフランの創出 [in Japanese] Development of a New Insecticide, Dinotefuran [in Japanese]
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Insecticides with a structure and mode of action similar to nicotine are called neonicotinoids, whose uses have expanded due to its high level of insecticidal activity against a wide variety of pests in many kinds of crops. Dinotefuran is a new neonicotinoid developed by Mitsui Chemicals and first registered in Japan in 2002. It has a characteristic tetrahydro-3-furylmethyl group instead of a pyridine ring or a thiazole ring that had been considered as indispensable for neonicotinoids. This group was discovered by the research stemming from acetylcholine as a lead compound to find the importance of a 3-methoxypropyl compound and its cyclization. It conferred new properties, high water solubility and different mode of action from other neonicotinoids upon dinotefuran.
- J. Synth. Org. Chem. Jpn.
J. Synth. Org. Chem. Jpn. 66(7), 716-720, 2008-07-01
The Society of Synthetic Organic Chemistry, Japan