高血圧自然発症ラットにおけるモリンガ葉水抽出物の抗高血圧作用 Antihypertensive Effect of Water Extracts from Leaves of Moringa oleifera Lam. on Spontaneously Hypertensive Rats

高血圧自然発症ラット（SHR）にモリンガ葉の10倍水抽出物を強制経口投与し，血圧上昇抑制効果について検討を行った．その結果，単回投与試験では血圧の有意な低下は認められなかったが，長期投与試験では，投与後25日目以降有意な血圧上昇抑制作用が認められた．また，モリンガ葉は，抗高血圧作用を有するGABAを高含有していた．モリンガ葉を長期間継続的に摂取することで高血圧発症を予防できる可能性があることが示唆された．

The antihypertensive effect of water extracts from leaves of Moringa oleifera Lam. was studied in spontaneously hypertensive rats (SHR). Extracts (10g of the dried leaves with 100ml of water) were given to SHR by a single oral administration at 3ml/kg body weight or by repeated oral administrations at 3ml/kg body weight/day for 6 weeks. The water extracts contained 0.3mg/ml of γ-aminobutyric acid (GABA). Although the single oral administration of the water extract could not reduce systolic blood pressure in SHR, repeated oral administration for 6 weeks resulted in significant decreases compared with the control. These results suggest that the daily intake of Moringa oleifera Lam. was effective for prevention against hypertension.