Amino Acid Mixture Identical to Vespa Larval Saliva Increases both Leptin Secretion and Basal Lipolysis in Rat Adipocytes

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著者

    • OGASAWARA Junetsu
    • Center for Intellectual Property Strategies, Sponsored Laboratory, The Institute of Physical and Chemical Research (RIKEN)
    • ABE Takashi
    • Center for Intellectual Property Strategies, Sponsored Laboratory, The Institute of Physical and Chemical Research (RIKEN)

抄録

The effect of vespa amino acid mixture solution (VAAM), a unique amino acid mixture identified in the saliva of the larva of a species of hornet endemic to Japan on adipocyte lipolysis was investigated in order to verify the possible mechanisms underlying the regulatory effect of VAAM on <I>in vivo</I> fat metabolism. VAAM significantly increased basal leptin secretion and lipolysis without an increase in cAMP production. However, VAAM failed to amplify either isoproterenol or dibutylyl cAMP-stimulated lipolysis, which is increased intracellular cAMP productions, accompanied by a significant decrease in leptin secretion. These results suggest that VAAM may enhance basal lipolysis independent of cAMP productions, but is dependant on leptin secretion from adipocytes themselves, at least in part.

収録刊行物

  • Food science and technology research  

    Food science and technology research 14(1), 95-98, 2008-01-01 

    Japanese Society for Food Science and Technology

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各種コード

  • NII論文ID(NAID)
    10021184765
  • NII書誌ID(NCID)
    AA11320122
  • 本文言語コード
    ENG
  • 資料種別
    NOT
  • ISSN
    13446606
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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