Suppression of Serum Cholesterol Levels in Mice by Adzuki Bean Polyphenols

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著者

    • NISHI Shigenori
    • Specialty of Science of Bioresources, United Graduate School of Agricultural Sciences, Iwate University
    • SAITO Yusuke
    • Specialty of Science of Bioresources, United Graduate School of Agricultural Sciences, Iwate University
    • SOUMA Chihiro
    • Biochemistry and Crop Quality Division, Hokkaido Central Agricultural Experiment Station
    • KATO Jun
    • Production research division, Hokkaido Prefectural Tokachi Agricultural Experiment Station
    • KOAZE Hiroshi
    • Specialty of Science of Bioresources, United Graduate School of Agricultural Sciences, Iwate University
    • HIRONAKA Kazunori
    • Specialty of Science of Bioresources, United Graduate School of Agricultural Sciences, Iwate University
    • KOJIMA Michiyuki
    • Specialty of Science of Bioresources, United Graduate School of Agricultural Sciences, Iwate University

抄録

When mice fed a high-cholesterol diet were given 0.5 ml of a solution of Adzuki polyphenols (Adzuki- PP; 4 mg/ml) for two weeks via a catheter, the atherosclerotic index of experimental mice was significantly lower than that of the control group, indicating a significant inhibitory effect of Adzuki-PP on serum cholesterol level. In addition, the fecal cholesterol level in the experimental group was significantly higher than that in the control group. Supplementation of Adzuki-PP to a concentration of 290 ppm lowered the solubility of micellar cholesterol in a concentration-dependent manner, indicating that Adzuki-PP inhibits cholesterol micellization. It was therefore suggested that the inhibitory effect of Adzuki-PP on cholesterol micellization in the digestive tract was associated with suppressed serum cholesterol levels.

収録刊行物

  • Food science and technology research  

    Food science and technology research 14(2), 217-220, 2008-03-01 

    Japanese Society for Food Science and Technology

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各種コード

  • NII論文ID(NAID)
    10021185207
  • NII書誌ID(NCID)
    AA11320122
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    13446606
  • データ提供元
    CJP書誌  J-STAGE 
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