Beneficial Effect of Honeybee-collected Pollen Lump Extract on Benign Prostatic Hyperplasia (BPH)-A Double-blind, Placebo-controlled Clinical Trial-

• MURAKAMI Maki

  Department of Surgery and Urology, Jishyukai Ueda Kidney Clinic

• TSUKADA Osamu

  Department of Surgery and Urology, Jishyukai Ueda Kidney Clinic

• OKIHARA Kiyoshi

  Institute for Bee Products and Health Science, Yamada Apiculture Center, Inc.

• HASHIMOTO Ken

  Institute for Bee Products and Health Science, Yamada Apiculture Center, Inc.

• YAMADA Hideo

  Institute for Bee Products and Health Science, Yamada Apiculture Center, Inc.

• YAMAGUCHI Hideyo

  Department of Surgery and Urology, Jishyukai Ueda Kidney Clinic

抄録

A double-blind, placebo-controlled clinical trial was performed to investigate the efficacy and safety of 12-week intake of honeybee-collected pollen lump extract (HPLE)-supplemented food in 47 patients with benign prostatic hyperplasia (BPH). The participants were randomly assigned to 3 study food trial groups: a placebo group (0 mg HPLE per day); a lower-dose group (160 mg HPLE per day); and a high-dose group (320 mg HPLE per day) (Groups P, L, and H, respectively). Outcome measures were the change during the 12-week intervention period in subjective symptom scores and 2 urodynamic parameters, maximum flow rate (Q_max) and residual urine volume. Q_max values were significantly increased in Group H (P<0.05) but not in Groups L or P. While residual urine volume was significantly increased in Groups L and P (P<0.05 each), the level in Group H decreased, although the difference between Groups H and P did not reach statistical significance (P=0.052). No HPLE-related health hazards or laboratory abnormalities of clinical significance were encountered.

収録刊行物

• Food Science and Technology Research

  Food Science and Technology Research 14 (3), 306-310, 2008

  公益社団法人 日本食品科学工学会

キーワード

• honeybee-collected pollen lump extract (HPLE)
• benign prostatic hyperplasia (BPH)
• lower urinary tract symptoms
• efficacy
• safety

詳細情報

• CRID: 1390282679432334976
• NII論文ID: 10021185490
• NII書誌ID: AA11320122
• DOI: 10.3136/fstr.14.306
• ISSN: 18813984
• ISSN: 13446606
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可