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- 廣瀬 伸一
- 福岡大学医学部小児科
書誌事項
- タイトル別名
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- Recent advance and perspectives in genetics of epilepsy
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The molecular pathogenesis of epilepsy had been long undiscovered though epilepsy was described even in ancient Greek age and has been well known as one of the commonest neurological disorders ever since. However, despite recent advances in molecular biology, the molecular mechanism of epilepsy remains a puzzle, assumingly due to its heterogeneous nature. Recently, genetic causes have been identified in certain epilepsy syndromes in which the inheritance is evident, such as progressive myoclonic epilepsy and rare familial idiopathic epilepsy syndromes. Interestingly, genetic abnormalities identified in such syndromes in which the phenotypes are similar to common idiopathic epilepsies were detected in genes encoding ion channels expressed in the brain. Thus such epilepsy syndromes are disorders of ion channels, i. e., “channelopathies”. The list of ion channel abnormalities that are associated with childhood epilepsy is expanding. Genetic identifier in epilepsy syndromes, except for severe myoclonic epilepsy in infancy, were familial epilepsy syndromes showing dominant inheritance with high penetrance while common idiopathic epilepsies do not show obvious inheritance. However, the similarities in symptomatology between such familial epilepsies and common idiopathic epilepsy may provide us with clues to the genetics of common idiopathic epilepsies. Further understanding of molecular mechanisms underlying epilepsy should open a new avenue to diagnosis and treatments for epilepsy based upon the pathomechanism.
収録刊行物
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- Japanese Journal of Clinical Chemistry
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Japanese Journal of Clinical Chemistry 35 (3), 250-260, 2006
一般社団法人 日本臨床化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204909692544
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- NII論文ID
- 130003357094
- 10021185974
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- NII書誌ID
- AN00252758
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- COI
- 1:CAS:528:DC%2BD28XovVCisbY%3D
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- ISSN
- 21874077
- 03705633
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可