Anterograde labeling of the corticospinal tract in jimpy mutant mice by DiI injection into the motor cortex

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著者

    • SHIBATA IWASAKI Riichi
    • Department of Anatomy and Developmental Neurobiology, Kobe University Graduate School of Medicine
    • DEKIMOTO Hideyuki
    • Department of Anatomy and Developmental Neurobiology, Kobe University Graduate School of Medicine
    • KATSUYAMA Yu
    • Department of Anatomy and Developmental Neurobiology, Kobe University Graduate School of Medicine
    • KIKKAWA Satoshi
    • Department of Anatomy and Developmental Neurobiology, Kobe University Graduate School of Medicine
    • TERASHIMA Toshio
    • Department of Anatomy and Developmental Neurobiology, Kobe University Graduate School of Medicine

抄録

Carbocyanine fluorescent dye, DiI, is an excellent anterograde/retrograde neural tracer, but its efficacy for the anterograde labeling of neural circuits in the adult brain tends to decrease with ages. The present study shows that an injection of DiI into the motor cortex of the young adult <I>jimpy</I> mutant mice (<I>Plp1<SUP>jp</SUP></I>/+) resulted in successful anterograde labeling of corticospinal tract fibers. Furthermore, an injection of Fast Blue into the lumbar spinal cord of the mutant mice resulted in retrograde labeling of layer 5 corticospinal tract neurons within the motor cortex. Since no abnormality except for myelin deficiency is known in the long descending and ascending tracts of <I>jimpy</I> mutant mouse, this mutant is suitable for neural tracing studies of long axonal trajectories with the use of carbocyanine dye, DiI, although these males die between 20 and 40 days of age

収録刊行物

  • Archives of histology and cytology  

    Archives of histology and cytology 70(5), 297-301, 2007-12-01 

    International Society of Histology and Cytology

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各種コード

  • NII論文ID(NAID)
    10021186967
  • NII書誌ID(NCID)
    AA1068990X
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09149465
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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