The differential distribution of type IV collagen a chains in the subepithelial basement membrane of the human alimentary canal

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著者

    • SATO Hiroyuki
    • Department of Human Morphology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • NAITO Ichiro
    • Department of Human Morphology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • MOMOTA Ryusuke
    • Department of Human Morphology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • NAOMOTO Yoshio
    • Department of Gastroenterological Surgery, Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • YAMATSUJI Tomoki
    • Department of Gastroenterological Surgery, Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • NINOMIYA Yoshifumi
    • Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • OHTSUKA Aiji
    • Department of Human Morphology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

抄録

We studied distribution patterns of type IV collagen α chains in the subepithelial basement membrane (SBM) of the human gastrointestinal tract - the esophagus through the anal canal - by immunofluorescent microscopy using α(IV) chain-specific monoclonal antibodies. The α1(IV), α2(IV), α5(IV), and α6(IV) chains were found in the SBM throughout the tract, indicating the localization of [α1(IV)]<SUB>2</SUB>α2(IV) and [α5(IV)]<SUB>2</SUB>α6(IV) heterotrimeric molecules. The [α1(IV)]<SUB>2</SUB>α2(IV) molecule was continuously stained, while the [α5(IV)]<SUB>2</SUB>α6(IV) molecule was weakly stained in gastric glands and small intestinal crypts. In addition, the SBM at the luminal surface epithelium of the stomach and large intestine contained small amounts of α3(IV) and α4(IV) chains which combined to form the α3(IV)α4(IV)α5(IV) heterotrimeric molecule with α5(IV) chain. The SBM beneath the villous epithelium of the small intestine was also demonstrated to have an α3(IV) chain and α4(IV) chain. Considering the specific locations of the type IV collagen trimers throughout the gastrointestinal SBM, the supramolecular network containing the α3(IV)α4(IV)α5(IV) molecule appears to function as a selective permeability barrier and /or as a protection against chemical stress from the luminal digestive enzymes.

収録刊行物

  • Archives of histology and cytology  

    Archives of histology and cytology 70(5), 313-323, 2007-12-01 

    International Society of Histology and Cytology

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各種コード

  • NII論文ID(NAID)
    10021187012
  • NII書誌ID(NCID)
    AA1068990X
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09149465
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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