A case of antiamphiphysin antibody-positive stiff-person syndrome with breast cancer diagnosed by FDG-PET

• Taguchi Yoshiharu

  The Department of Neurology, Toyama University Hospital

• Takashima Shutaro

  The Department of Neurology, Toyama University Hospital

• Inoue Yuukichi

  The Department of Neurology, Toyama Koshi Rehabilitation Hospital

• Nagata Takuya

  The Second Department of Surgery, Toyama University Hospital

• Shimizu Masashi

  The Department of Radiology, Toyama University Hospital

• Tanaka Kortaro

  The Department of Neurology, Toyama University Hospital

Bibliographic Information

Other Title

• ＦＤＧ‐ＰＥＴが診断に有用であった抗ａｍｐｈｉｐｈｙｓｉｎ抗体陽性ｓｔｉｆｆ‐ｐｅｒｓｏｎ症候群の１例
• 症例報告 FDG-PETが診断に有用であった抗amphiphysin抗体陽性stiff-person症候群の1例
• ショウレイ ホウコク FDG PET ガ シンダン ニ ユウヨウ デ アッタ コウamphiphysin コウタイ ヨウセイ stiff person ショウコウグン ノ 1レイ

Abstract

We report a case of antiamphiphysin antiboddy-positive stiff-person syndrome associated with breast cancer, which was detected only by FDG-PET. A 46-year-old woman was admitted to our hospital because of painful muscle cramp and stiffness of both legs. Laboratory results were negative for anti-GAD antibody, but highly positive for antiamphiphysin antibody (1: 61,440). She had been diagnosed as having paraneoplastic stiff-person syndrome. However, mammogram, thoracic CT, breast MRI and ultrasonic echography showed no abnormal findings. A whole-body fluorodeoxyglucose (FDG) PET was performed, showing an increased uptake in the left axillary lymph nodes. Then, the left axillary lymph nodes were resected and immunohistochemically diagnosed as breast adenocarcinoma. Treatment of stiff-person syndrome was initiated with corticosteroids followed by chemotherapy against breast cancer, which led to a remarkable improvement of her neurological symptoms. If there is possibility of paraneoplastic syndromes like stiff-person syndrome, FDG-PET is very useful for detecting the occult carcinoma.<br>

Journal

• Rinsho Shinkeigaku

  Rinsho Shinkeigaku 48 (6), 410-414, 2008

  Societas Neurologica Japonica

Keywords

• stiff-person syndrome
• antiamphiphysin antibody
• FDG-PET
• breast cancer
• steroid therapy

Details

• CRID: 1390282680011174016
• NII Article ID: 10021187761
• NII Book ID: AN00253207
• DOI: 10.5692/clinicalneurol.48.410
• ISSN: 18820654
• ISSN: 0009918X
• NDL BIB ID: 9553141
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9553141
• Web Site: https://search.jamas.or.jp/link/ui/2008257456
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed