書誌事項
- タイトル別名
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- Clinical features of 15 cases treated with linezolid
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We investigated the clinical features of 15 cases treated with linezolid (LZD). The patients ranged in age from 0 to 80 years old (mean: 66 years old). Fifteen strains were isolated as pathogens: 11 strains of methicillin-resistant Staphylococcus aureus (MRSA), 3 strains of methicillin-resistant Staphylococcus epidermidis (MRSE), and 1 strain of methicillin-sensitive Staphylococcus aureus (MSSA). The clinical diagnosis was sepsis in 4 cases, infective arthritis in 4, pneumonia in 2, infective endocarditis in 2, osteomyelitis in 2, deep soft tissue and skin infections in 2, mediastinitis in 1, and meningitis in 1 case. The reasons for LZD use were resistance to previous treatment in 10 cases, renal dysfunction in 5, and intolerance to glycopeptides in 4 cases. As for the adverse effects of LZD, anemia in 4 cases, thrombocytepenia in 3, and liver damage in 1 case were recognized. These results suggest that LZD is effective for the complicated infections caused by Grampositive cocci, such as MRSA or methicillin-resistant coagulase negative Staphylococci (MRCNS), and is better tolerance. However, LZD should be given to carefully selected patients, in order to prevent the appearance of LZD-resistant bacteria
収録刊行物
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- 日本化学療法学会雑誌
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日本化学療法学会雑誌 56 (2), 202-205, 2008
公益社団法人 日本化学療法学会
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詳細情報 詳細情報について
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- CRID
- 1390282681261648128
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- NII論文ID
- 130004298362
- 10021192516
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- NII書誌ID
- AN10472127
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- ISSN
- 18845886
- 13407007
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可