高齢者におけるsitanoxacinの体内動態

• 関野 久邦

  関野病院

書誌事項

タイトル別名

• Pharmacokinetic profiles of sitafloxacin in elderly volunteers

抄録

The effect of aging on the pharmacokinetic profile of sitafloxacin (STFX) was investigated by comparing 5 elderly (>65 years) and 6 non elderly (=20 to <40 years) male volunteers.<BR>Following a single oral administration of 100mg of STFX, elderly volunteers showed delayed t_max, prolonged t_1/2, decreased renal clearance, and increased AUC_0-24h compared to non elderly volunteers. No notable differences were observed in cumulative urinary excretion (0-48h). No significant adverse drug reactions were observed in either groups.

収録刊行物

• 日本化学療法学会雑誌

  日本化学療法学会雑誌 56 (Supplement1), 18-20, 2008

  公益社団法人 日本化学療法学会

キーワード

• sitafloxacin
• elderly
• pharmacokinetics
• fluoroquinolone

詳細情報

• CRID: 1390282681264813440
• NII論文ID: 10021192757
• NII論文ID: 130004102783
• NII書誌ID: AN10472127
• DOI: 10.11250/chemotherapy1995.56.supplement1_18
• ISSN: 18845886
• ISSN: 13407007
• Web Site: https://search.jamas.or.jp/link/ui/2008207504
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可