Sitafloxacin第I相臨床試験

• 中島 光好

  浜松シーピーティー研究所

書誌事項

タイトル別名

• Pharmacokinetics of sitafloxacin (DU-6859a) in healthy volunteers
• ノンコンパートメント

抄録

We studied the pharmacokinetics of sitafloxacin (STFX) in healthy male volunteers given single oral doses 25 mg, 50 mg, 100 mg (fasting and non fasting state), or 200 mg. Non compartmentalanalysis was used to calculate pharmacokinetic parameters of STFX. C_max of 0.29, 0.51, 1.00, 0.88, and 1.86 of serum appeared within 1 to 2 h after administration. After C_max was reached, serum drug levels decreased with elimination half-lives of 5 to 6 h. C_max and AUC_0-inf increased in a dose proportional manner. We found a goodlinear correlation between administered doses and resulting C_max and AUC_0-inf. Food intake did not significantly influence STFX pharmacokinetics.

収録刊行物

• 日本化学療法学会雑誌

  日本化学療法学会雑誌 56 (Supplement1), 154-155, 2008

  公益社団法人 日本化学療法学会

キーワード

• sitafloxacin
• pharmacokinetics
• fluoroquinolone
• phase I study

詳細情報

• CRID: 1390282681264814592
• NII論文ID: 10021192934
• NII論文ID: 130004102782
• NII書誌ID: AN10472127
• DOI: 10.11250/chemotherapy1995.56.supplement1_154
• ISSN: 18845886
• ISSN: 13407007
• Web Site: https://search.jamas.or.jp/link/ui/2008207519
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可