Immune Enhancing Properties of Safflower Leaf (Carthamus tinctorius) on Chicken Lymphocytes and Macrophages
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- Lee Sung-Hyen
- Animal and Natural Resources Institute, Beltsville Agricultural Research Center, ARS, USDA, USA National Rural Resources Development Institute, NIAST, RDA, 88-2 Seodun-dong, Korea
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- Lillehoj Hyun S.
- Animal and Natural Resources Institute, Beltsville Agricultural Research Center, ARS, USDA, USA
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- Heckert Robert A.
- Animal and Natural Resources Institute, Beltsville Agricultural Research Center, ARS, USDA, USA
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- Cho Soo-Muk
- National Rural Resources Development Institute, NIAST, RDA, 88-2 Seodun-dong, Korea
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- Tuo Wenbin
- Animal and Natural Resources Institute, Beltsville Agricultural Research Center, ARS, USDA, USA
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- Lillehoj Erik P.
- Department of Pediatrics, School of Medicine, University of Maryland, Baltimore, USA
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- Chun Hye-Kyung
- National Rural Resources Development Institute, NIAST, RDA, 88-2 Seodun-dong, Korea
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- Park Hong-Ju
- National Rural Resources Development Institute, NIAST, RDA, 88-2 Seodun-dong, Korea
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抄録
Safflower (Carthamus tinctorius) has been used as a traditional medicinal plant to enhance natural immunity and treat cancers. However, limited information exists on the mechanisms responsible for its immune enhancing properties. In this study, the immunostimulatory effects of a methanol extract of safflower leaf were assessed by in vitro lymphocyte proliferation, tumor cell cytotoxicity, and nitric oxide production by cultured chicken macrophages. A crude methanol extract of safflower leaf stimulated spleen lymphocyte proliferation and nitric oxide production, and inhibited the viability of tumor cells significantly greater than medium controls. Sequential gel filtration chromatographic separation of the methanol extract on Sephadex G-25 and Sephacryl S-200 columns resulted in a partially purified preparation that retained the ability to induce lymphoproliferation, tumor killing, and NO production. These results demonstrate for the first time that safflower leaf contains immunostimulatory and anti-tumor component(s) that may be potentially useful as a dietary immunomodulator for poultry.
収録刊行物
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- The Journal of Poultry Science
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The Journal of Poultry Science 45 (2), 147-151, 2008
日本家禽学会
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詳細情報 詳細情報について
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- CRID
- 1390001205207191296
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- NII論文ID
- 10021220262
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- NII書誌ID
- AA11564513
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- ISSN
- 13490486
- 13467395
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- NDL書誌ID
- 9469281
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可