犬の鼻腔悪性腫瘍に対する放射線治療(大線量・小分割・多門照射)の効果 The Effects of High-dosed, Hypofractionated, Multiple-field Radial Irradiation to Dogs with Malignant Nasal Tumor

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多門照射で大線量小分割の放射線治療を行った犬の鼻腔悪性腫瘍18例について回顧的調査を実施した。放射線治療は4MVのX線を1回線量中央値9Gy(幅5~10Gy)週1回で用い,照射回数が17例で4回,1例で3回,照射総線量は中央値36Gy(幅30Gy~40Gy)であった。臨床徴候の改善は16例で得られ,放射線治療終了後1~2カ月目にCTを撮影した16例のうち腫瘤の縮小が9例で認められた。生存期間中央値は350日(幅,92~1141日)で,顔面変形と篩板破壊が認められたものは有意に生存期間が短かった(ともに中央値224日)。放射線障害としては急性障害が18例中5例(脱毛5例,結膜炎2例),晩発障害が18例中7例(全例,毛色の変化)で認められたがすべて軽度であり治療は不要であった。このことから,犬の鼻腔悪性腫瘍に対する大線量小分割での多門照射はQOLを低下することなく治療効果および延命効果が得られ,有効な治療と思われた。

We reviewed retrospectively 18 canine cases of malignant tumor in the nasal cavity treated with high-dosed, hypofractionated, and multiple-field radiography. Seventeen dogs were irradiated four times, and the remaining one was irradiated three times; the dose of irradiation at one time was in the range of 5 to 10 Gy, and the median was 9 Gy. The total dose of irradiation was in the range of 30 to 40 Gy, and the median was 36 Gy. Out of 16 cases where the clinical symptoms were improved, CT scanned images taken one to two months later showed lessened tumors in 9 cases. The median survival period of time was 350 days (range 92 to 1141 days). The survival period was significantly shorter in two groups with facial deformity or distruction of the cribriform lamina, and the median survival periods were 224 days in both groups. Regarding adverse effects of radiography, acute adverse effects such as depilation and conjunctivitis were seen, and late adverse effects such as change of hair color were also seen. However, they were mild, and needed no treatment. These findings indicate that high-dosed, hypofractionated, and multiple-field radial irradiation is effective against malignant tumor of the nasal cavity in dogs, and provides size reduction of tumor and prolonged survival period, without harming the dogs' quality of life.

収録刊行物

  • 動物臨床医学 = Journal of Animal Clinical Research Foundation  

    動物臨床医学 = Journal of Animal Clinical Research Foundation 17(1), 1-6, 2008-03-20 

    動物臨床医学会

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