犬の鼻腔悪性腫瘍に対する放射線治療(大線量・小分割・多門照射)の効果 [in Japanese] The Effects of High-dosed, Hypofractionated, Multiple-field Radial Irradiation to Dogs with Malignant Nasal Tumor [in Japanese]
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We reviewed retrospectively 18 canine cases of malignant tumor in the nasal cavity treated with high-dosed, hypofractionated, and multiple-field radiography. Seventeen dogs were irradiated four times, and the remaining one was irradiated three times; the dose of irradiation at one time was in the range of 5 to 10 Gy, and the median was 9 Gy. The total dose of irradiation was in the range of 30 to 40 Gy, and the median was 36 Gy. Out of 16 cases where the clinical symptoms were improved, CT scanned images taken one to two months later showed lessened tumors in 9 cases. The median survival period of time was 350 days (range 92 to 1141 days). The survival period was significantly shorter in two groups with facial deformity or distruction of the cribriform lamina, and the median survival periods were 224 days in both groups. Regarding adverse effects of radiography, acute adverse effects such as depilation and conjunctivitis were seen, and late adverse effects such as change of hair color were also seen. However, they were mild, and needed no treatment. These findings indicate that high-dosed, hypofractionated, and multiple-field radial irradiation is effective against malignant tumor of the nasal cavity in dogs, and provides size reduction of tumor and prolonged survival period, without harming the dogs' quality of life.
- J Anim Clin Med
J Anim Clin Med 17(1), 1-6, 2008-03-20
Japanese Society of Clinical Veterinary Medicine