BART is essential for nuclear retention of STAT3

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著者

    • MUROMOTO Ryuta
    • Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
    • SEKINE Yuichi
    • Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
    • IMOTO Seiyu
    • Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
    • IKEDA Osamu
    • Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
    • OKAYAMA Taichiro
    • Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
    • SATO Noriko
    • Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
    • MATSUDA Tadashi
    • Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University

抄録

Signal transducers and activators of transcription (STATs) mediate cell proliferation, differentiation, and survival in immune responses, hematopoiesis, neurogenesis, and other biological processes. STAT3, for example, is involved in the epithelialmesenchymal transition during gastrulation, organogenesis, wound healing, and cancer progression. STAT activity is regulated by a variety of mechanisms, including nuclear translocation. To clarify the molecular mechanisms underlying the regulation of STAT activity, we performed yeast two-hybrid screening. Here we identified BART (Binder of ADP-ribosylation factor-like Two) as a novel STAT-binding partner. Importantly, we showed that BART is essential for the transcriptional activity and nuclear retention of STAT3. Furthermore, an effector of BART, ADP-ribosylation factor-like 2 (ARL2) was also involved in nuclear retention of STAT3. These results indicate that BART plays an essential role in the nuclear retention of STAT3 through interaction with ARL2.

収録刊行物

  • International immunology  

    International immunology 20(3), 395-403, 2008-03-01 

    Oxford University Press

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