BART is essential for nuclear retention of STAT3

• Muromoto, Ryuta

• Sekine, Yuichi

• Imoto, Seiyu

• Ikeda, Osamu

• Okayama, Taichiro

• Sato, Noriko

• Matsuda, Tadashi

Bibliographic Information

Other Title

• Interactions between STAT3 and BART

Abstract

Signal transducers and activators of transcription (STATs) mediate cell proliferation, differentiation, and survival in immune responses, hematopoiesis, neurogenesis, and other biological processes. STAT3, for example, is involved in the epithelialmesenchymal transition during gastrulation, organogenesis, wound healing, and cancer progression. STAT activity is regulated by a variety of mechanisms, including nuclear translocation. To clarify the molecular mechanisms underlying the regulation of STAT activity, we performed yeast two-hybrid screening. Here we identified BART (Binder of ADP-ribosylation factor-like Two) as a novel STAT-binding partner. Importantly, we showed that BART is essential for the transcriptional activity and nuclear retention of STAT3. Furthermore, an effector of BART, ADP-ribosylation factor-like 2 (ARL2) was also involved in nuclear retention of STAT3. These results indicate that BART plays an essential role in the nuclear retention of STAT3 through interaction with ARL2.

Journal

• International Immunology

  International Immunology 20 (3), 395-403, 2008-03

  Oxford University Press

Keywords

• STAT3
• BART
• IL-6
• LIF
• nuclear retention
• signal transduction

Details

• CRID: 1050845763926496000
• NII Article ID: 10021239970
• NII Book ID: AA10730708
• ISSN: 14602377
• ISSN: 09538178
• HANDLE: 2115/38124
• Web Site: https://search.jamas.or.jp/link/ui/2008230763
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles