Two Female Siblings with Childhood-Onset Systemic Lupus Erythematosus

• SANO Fumie

  Department of Pediatrics, Yokohama City University School of Medicine

• OZAWA Remi

  Department of Pediatrics, Yokohama City University School of Medicine

• MACHIDA Hiroyuki

  Department of Pediatrics, Yokohama City University School of Medicine

• MIYAMAE Takako

  Department of Pediatrics, Yokohama City University School of Medicine

• ITO Shuichi

  Department of Pediatrics, Yokohama City University School of Medicine

• IMAGAWA Tomoyuki

  Department of Pediatrics, Yokohama City University School of Medicine

• MORI Masaaki

  Department of Pediatrics, Yokohama City University School of Medicine

• OKUYAMA Kenichi

  Department of Pediatrics, Kanagawa Prefectural Ashigara Kami Hospital

• YOKOTA Shumpei

  Department of Pediatrics, Yokohama City University School of Medicine

Bibliographic Information

Other Title

• 小児期発症全身性エリテマトーデスの姉妹例

Abstract

  We herein report two female siblings with childhood-onset Systemic Lupus Erythematosus (SLE) who developed membranous lupus nephritis. The children were diagnosed as having SLE in reverse birth order at ages 11 and 14 years. Younger sister's initial symptom was edema and laboratory findings indicated proteinurea, hypocomplementemia and positive ANA/anti-dsDNA antibody. She was diagnosed as being SLE with membranous lupus nephritis based on International Society of Nephrology/Renal Pathology Society (ISN/RPS) 2003 classification. Elder sister manifested general fatigue and edema twelve months after her sister. Laboratory findings showed proteinurea, hypocomplementemia, and positive ANA/anti-dsDNA antibody. A renal biopsy revealed mixed form of mesangial proliferative glomerulonephritis and membranous nephritis. Moreover, both of them were complicated with secondary Sjögren's syndrome. HLA typing was performed and the siblings were noted to have the same haplotype; A^*0207, A^*2402, B^*4601, B^*5201, B^*5201, Cw^*0102, Cw^*1202, DRB1^*0101, DRB1^*0803.<br>

Journal

• Japanese Journal of Clinical Immunology

  Japanese Journal of Clinical Immunology 31 (3), 172-177, 2008

  The Japan Society for Clinical Immunology

Keywords

• Systemic lupus erythematosus
• child
• Siblings
• lupus nephritis
• HLA

Details

• CRID: 1390001204649932288
• NII Article ID: 10021242730
• NII Book ID: AN00357971
• DOI: 10.2177/jsci.31.172
• ISSN: 13497413
• ISSN: 09114300
• Web Site: http://www.jstage.jst.go.jp/article/jsci/31/3/31_3_172/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008273519
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed