Genetically Confirmed Nosocomial Transmission of Staphylococcal Scalded Skin Syndrome between Two Infants in the Neonatal Intensive Care Unit

DOI Web Site 1 Citations 10 References

Bibliographic Information

Other Title
  • NICU内での水平感染が遺伝子解析で証明しえたブドウ球菌性熱傷様皮膚症候群の2症例
  • 症例 NICU内での水平感染が遺伝子解析で証明しえたブドウ球菌性熱傷様皮膚症候群の2症例
  • ショウレイ NICUナイ デノ スイヘイ カンセン ガ イデンシ カイセキ デ ショウメイシエタ ブドウ キュウキンセイ ネッショウヨウ ヒフ ショウコウグン ノ 2 ショウレイ

Search this article

Abstract

We report two consecutive cases of staphylococcal scalded skin syndrome (SSSS) in our neonatal intensive care unit (NICU). Methicillin-resistantStaphylococcus aureus(MRSA) was isolated from skin swabs. An epidemiological survey conducted on the NICU staff, isolated MRSA from nasal swabs of three personnel. Gene analysis of these five isolates using pulsed-field gel electrophoresis (PFGE) of the bacterial genome and polymerase chain reaction (PCR) for a panel of toxin genes encoded two patient-derived isolates of exfoliative toxin B (ETB) considered to be identical based on the spectrum of toxin genes encoded and PFGE patterns. Three staff-derived isolates did not, however, encode ETB and showed different repertoires of toxin genes and PFGE patterns from those of the two patient-derived isolates. Nasal application of mupirocin to all carriers successfully eradicated MRSA. Horizontal transmission of ETB-producing MRSA between the two patients in the NICU was confirmed, but no NICU personnel carried the same isolate. We therefore wish to emphasize the importance of strict standard and contact precautionary measures and the monitoring of MRSA in the NICU, together with the usefulness of gene analysis using PFGE and PCR as epidemiological tools.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 82 (1), 34-37, 2008

    The Japanese Association for Infectious Diseases

Citations (1)*help

See more

References(10)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top