Efficacy of an Alcohol-based Hand Rub Containing Synthetic Pseudo-ceramide for Reducing Skin Roughness of the Hand

• TSUBOI Ryoji

  Department of Dermatology, Tokyo Medical University

• ARAT Keitaro

  Department of Dermatology, Tokyo Medical University

• SUMIDA Haruko

  Department of Dermatology, Tokyo Medical University

• NISHIO Masaya

  Performance Chemicals Research Laboratories, Kao Corporation

• HASEBE Keiko

  Performance Chemicals Research Laboratories, Kao Corporation

• HIOMKI Yuichi

  Scholarly Information Department, Kao Professional Service Co., Ltd.

• OKUDA Minehiro

  Safety and Microbial Control Research Center, Kao Corporation

Bibliographic Information

Other Title

• 合成擬似セラミド含有速乾性擦式手指消毒薬の手荒れ抑制効果
• ゴウセイ ギジ セラミド ガンユウ ソッカンセイサツシキ シュシ ショウドクヤク ノ テアレ ヨクセイ コウカ

Abstract

Recently, alcohol-based hand rubs have become popular for hand hygiene. The alcohol-based hand rubs containing emollients are preferred to other forms, since frequent use of hand rubs may cause roughness of the hand skin. This study investigated the efficacy of an alcohol-based hand rub containing synthetic pseudo-ceramide for reducing the roughening of the hand skin.<BR>The subjects used three alcohol-based hand rub formulae designed for health-care professionals over a period of three weeks. Each formula contained 0.2 w/v% benzalkonium chloride and 83 vol % ethanol. The SP formula (N=11) contained synthetic pseudo-ceramide as an emollient, the NF formula (N=10) contained NMF and propylene glycolas emollients, and the PL formula (N=10) contained no emollient. Clinical observations of skin appearance, measurement of skin conductance value and TEWL, and a questionnaire were administered 3 times, before use, after one week, and after two weeks of use. The SP formula improved the skin condition in 8 of 11 subjects, whereas no improvement in skin condition was observed in the subjects using the NF formula. The PL formula aggravated the skin condition of 6 of 10 subjects. Both the SP and the NF formulae were reported to have no sticky feeling and no inconvenience in usual operations after use.<BR>The present study suggests alcohol-based hand rubs containing emollients are less likely to roughen the skin of the hands in comparison with hand rubs containing no emollient. In particular, the alcohol-based hand rub containing synthetic pseudo-ceramide appears to be ideal for use in handhygiene, because of the relative mildness, no sticky feeling, and ease of use.

Journal

• Environmental Infections

  Environmental Infections 21 (2), 73-80, 2006

  Japanese Society of Environmental Infections

Keywords

• alcohol-based hand rub
• synthetic pseudo-ceramide
• roughening hand skin

Details

• CRID: 1390001204437668096
• NII Article ID: 10021243180
• NII Book ID: AN1019475X
• DOI: 10.11550/jsei1986.21.73
• ISSN: 18842429
• ISSN: 09183337
• NDL BIB ID: 8030817
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8030817
• Web Site: https://search.jamas.or.jp/link/ui/2006258813
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • CiNii Articles
• Abstract License Flag: Disallowed