Ｃｌｏｓｔｒｉｄｉｕｍ　ｄｉｆｆｉｃｉｌｅ関連下痢症における再発の予測

• 高橋 利弘

  熊本労災病院内科

• 丸山 久美子

  熊本労災病院薬剤部

書誌事項

タイトル別名

• Prediction of Recurrence of Clostridium Difficile-associated Diarrhea
• Clostridium difficile カンレン ゲリショウ ニ オケル サイハツ ノ ヨソク

抄録

Clostridium difficile-associated diarrhea (CDAD) recurs in 15-20% of patients, resulting in decreased quality of life, prolongation of hospitalization, and increased medical expenses. CDAD recurred in 9 of the 29 patients treated for CDAD at our hospital between April 2005 and July 2005 (and followed until September 2005). This study compared clinical data and the Toxin A level measured using a VIDAS Assay kit CDA2 between the 9 patients with recurrent CDAD and the 20 patients with a single episode to investigate the possibility of predicting the recurrence of CDAD. No significant differences in clinical data were noted between the single-episode and recurrence groups, but the Toxin A level measured at the time of diagnosis was significantly higher in the recurrence group than in the single-episode group (20.9±2.2 vs. 8.3±2.2, p<0.05). However, following adjustment of the bacterial suspension to McFarland 3.0 to normalize the bacterial count, there was no significant difference between the two groups (3.0±1.0 vs. 2.8±1.8), suggesting that the difference in bacterial count affected recurrence. These findings suggest that measurement of Toxin A using a VIDAS Assay kit CDA2 may be useful for prediction of the recurrence of CDAD, so allowing appropriate preventive treatment.

収録刊行物

• 環境感染

  環境感染 21 (4), 254-257, 2006

  日本環境感染学会

キーワード

• 再発

詳細情報

• CRID: 1390001204437010944
• NII論文ID: 10021243494
• NII書誌ID: AN1019475X
• DOI: 10.11550/jsei1986.21.254
• ISSN: 18842429
• ISSN: 09183337
• NDL書誌ID: 8641572
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8641572
• Web Site: https://search.jamas.or.jp/link/ui/2007133683
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可