Detection of Specific IgE Antibodies in Sera of Japanese Birch-Allergic Patients Using Recombinant Allergens Bet v 1, Bet v 2 and Bet v 4

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  • Shirasaki Hideaki
    Department of Otolaryngology, Sapporo Medical University, School of Medicine
  • Yamamoto Tetsuo
    Yamamoto ENT Clinic
  • Koyanagi Yoko
    Department of Clinical Laboratory Medicine, Sapporo Medical University, School of Medicine
  • Watanabe Naoki
    Department of Clinical Laboratory Medicine, Sapporo Medical University, School of Medicine
  • Himi Tetsuo
    Department of Otolaryngology, Sapporo Medical University, School of Medicine

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Background: Birch pollen is the major allergen in pollinosis in northern Japan. IgE reactivity to individual birch pollen allergens has been shown to differ between populations of birch pollen-allergic patients living in different countries. In this study, we examined the IgE profiles to recombinant birch pollen allergens in birch-sensitive patients living in Sapporo.<br> Methods: This study used the sera of 40 patients with specific IgE toward birch pollen extract. Their sera were analyzed for specific IgE reactivity to individual birch pollen allergens (recombinant Bet v 1, Bet v 2 and Bet v 4) and natural birch pollen extract using Pharmacia CAP SystemTM.<br> Results: Of 40 sera with positive CAP results for natural birch pollen extract, 39 (97.5%) had specific IgE towards Bet v 1; 6 (15%) contained specific IgE against Bet v 2. Bet v 4 reactivity was documented in only one subject (2.5%).<br> Conclusions: The present data suggest that the specific IgE reactivity profiles to birch pollen allergen in birch-sensitive patients in Sapporo correspond to those in Scandinavia, possibly due to the heavy birch pollen exposure in this area. This observation provides useful information for future birch allergen-specific immunotherapy in Japan.<br>

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