IgE Profiles of Bermuda Grass Pollen Sensitised Patients Evaluated by Phleum Pratense Allergens Phl P 1, 2, 4, 5, 6 , 7, 11, 12

• Rossi Renato E

  Allergy Unit, National Health Service, Rete di Allergologia, Regione Piemonte

• Monasterolo Giorgio

  Dipartimento di Analisi Chimico-Cliniche e Microbiologia, Ospedali di Fossano e Savigliano

• Prina Paolo

  Deparment of Otorhinolaryngology, Ospedale SS Annunziata

• Coco Giuseppe

  Dipartimento di Analisi Chimico-Cliniche e Microbiologia, Ospedali di Fossano e Savigliano

• Operti Daniela

  Dipartimento di Analisi Chimico-Cliniche e Microbiologia, Ospedali di Fossano e Savigliano

• Rossi Lucilla

  Department of General Pathology, University of Genoa

抄録

Background: Despite the difference in geographical dominance of certain grasses, a high degree of allergenic similarity or cross-reactivity between Bermuda grass pollen (BGP) and timothy grass pollen (TGP) has been previously demonstrated.<br> The aim of the present study was to ascertain the sensitisation to TGP in 411 patients known for their reactivity to BGP extracts by analysing their reactivity to crude timothy pollen extract and timothy pollen purified allergens, establishing their specific IgE-profiles.<br> Methods: Using the immunoenzymatic CAP method we evaluated IgE-specific antibodies for BGP- and TGP- extracts and the timothy recombinant (r) and natural (n) allergens rPhl p 1, rPhl p 2, nPhl p 4, rPhl p 5, rPhl p 6, rPhl p 7, rPhl p 11, and rPhl p 12.<br> Results: BGP-IgE positive patients (median = 8.0kUA/l, 2.8-22.2kUA/l 25^th-75^th percentile) simultaneously had IgE positive results for TGP (100% of subjects) (median = 48.9kUA/l, 19.8- > 100kUA/l 25^th-75^th percentile) and high prevalence of sensitization to 6/8 Phleum pratense allergens (Phl p 1, 2, 4, 5, 6, 11, markers of genuine sensitisation to TGP) other than profilin and calcium binding protein. More than 72% of BGP allergic patients were co-sensitised to rPhl p 1, rPhl p 2, nPhl p 4, rPhl p 5, rPhl p 6. A decrease of total and specific IgE with patients' age was observed.<br> Conclusions: Our data show that all BGP-allergic patients simultaneously exhibit higher IgE antibody levels to recombinant and natural P. pratense allergens as well as to crude TGP extract. This suggests that when choosing an immunotherapeutic regimen for BGP-sensitised patients (after establishing their IgE profile via purified TGP-allergens), subcutaneous or sublingual TGP-extract vaccines in appropriate doses, in order to influence T epitope specificity, might be beneficial. Though extremely uncommon, in cases where a patient is exclusively BGP allergen-sensitised, BGP-extract therapy is the appropriate therapeutic response.<br>

収録刊行物

• Allergology International

  Allergology International 57 (2), 157-164, 2008

  一般社団法人日本アレルギー学会

キーワード

• Bermuda grass
• recombinant allergens
• timothy grass

詳細情報

• CRID: 1390282679608796672
• NII論文ID: 10021246619
• NII論文ID: 130004476969
• NII書誌ID: AA11091750
• DOI: 10.2332/allergolint.o-07-503
• ISSN: 14401592
• ISSN: 13238930
• Web Site: http://api.elsevier.com/content/article/PII:S132389301530767X?httpAccept=text/xml
• Web Site: http://api.elsevier.com/content/article/PII:S132389301530767X?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2008357970
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
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