A 13-year Study of Japanese Cedar Pollinosis in Japanese Schoolchildren

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  • Ozasa Kotaro
    Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
  • Hama Takemitsu
    Department of Otorhinolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine
  • Dejima Kenji
    Kyoto Second Red Cross Hospital
  • Watanabe Yoshiyuki
    Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
  • Hyo Sawako
    Department of Otorhinopharyngolaryngology, Osaka Medical College
  • Terada Tetsuya
    Department of Otorhinopharyngolaryngology, Osaka Medical College
  • Araki Natsuko
    Department of Otorhinopharyngolaryngology, Osaka Medical College
  • Takenaka Hiroshi
    Department of Otorhinopharyngolaryngology, Osaka Medical College

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Abstract

Background: Japanese cedar pollen (JCP) sensitization and Japanese cedar pollinosis (JCPS) appear to be increasingly prevalent in younger children. The present study investigated factors affecting JCP sensitization and JCPS development in school children.<br> Methods: In May or June each year from 1994 to 2006, 275-510 children were assessed for serum JCP-IgE and house dust mite (HDM)-IgE levels, and surveyed regarding rhinoconjunctival symptoms.<br> Results: Strong JCP sensitization (IgE ≥ 17.5UA/ml) was associated with age (odds ratio (OR) = 2.65), the amount of dispersed pollen in the observed year (OR = 2.03) and in the year following birth (OR = 1.51), the month of birth (OR = 2.18), and the recent birth cohort (OR = 1.96). Symptoms were negatively correlated with the recent birth cohort (OR = 0.69) after adjusting for JCP-IgE levels. Strong HDM sensitization was associated with gender (OR = 0.65 for girls) and the recent birth cohort (OR = 1.76).<br> Conclusions: JCP sensitization appeared to be associated with the recent birth cohort and to increases in dispersed pollen just after birth and in the observed season. Although the recent birth cohort was more easily sensitized, they were not more likely to develop symptoms. In contrast to JCP sensitization, strong HDM sensitization appeared to develop prior to commencement of primary school and was more likely to affect boys.<br>

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