Association of High Proliferation in Adult T-cell Leukemia Cells With Apoptosis, and Expression of p53 Protein in Acute Type ATL

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著者

    • WANG Jia
    • Divsion of Persistent & Oncogenic Viruses (Center for Chronic Viral Diseases), Field of Infection and Immunity, Course of Health Research, Kagoshima University Graduate School of Medical and Dental Sciences
    • HASUI Kazuhisa
    • Divsion of Persistent & Oncogenic Viruses (Center for Chronic Viral Diseases), Field of Infection and Immunity, Course of Health Research, Kagoshima University Graduate School of Medical and Dental Sciences
    • MATSUYAMA Takami
    • Department of Immunology, Field of Infection and Immunity, Course of Health Research, Kagoshima University Graduate School of Medical and Dental Sciences

抄録

Proliferation, apoptosis and p53 protein expression in adult T-cell leukemia (ATL) cells were investigated. Twenty peripheral blood tissue specimens (PBTS) comprising 7 cases of acute type ATL, 7 cases of chronic type ATL and 6 other leukemias were examined by means of antigen retrieval and the polymer method employing anti-Ki67 antigen (MIB-1), anti-cleaved caspase-3, anti-single stranded DNA and three kinds of anti-p53 protein antibodies including DO7. Most acute and chronic cases of ATL included more than 10% MIB-1-positive proliferating leukemia cells and more than 1% cleaved caspase-3-positive apoptotic cells. Some cells which were positive for both MIB-1 and anti-cleaved caspase-3 antibody were observed in acute type ATL. Nuclear deposition of p53 protein labeled by DO7 was often found in acute type (p < 0.05). Within the medium-sized population of ATL cell nuclei, DO7-positive ATL cells had a smaller nuclear area factor (long axis x short axis) than DO7-negative ATL cells. A few proliferating ATL cells entered apoptosis, and the appearance of a subclone of ATL cells with nuclear deposition of p53 protein labeled by DO7 characterized acute type. [<I>J Clin Exp Hematopathol 48(1) : 1-10, 2008</I>]

収録刊行物

  • Journal of clinical and experimental hematopathology  

    Journal of clinical and experimental hematopathology 48(1), 1-10, 2008-05-01 

    The Japanese Society for Lymphoreticular Tissue Research

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各種コード

  • NII論文ID(NAID)
    10021246669
  • NII書誌ID(NCID)
    AA11556796
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13464280
  • データ提供元
    CJP書誌  J-STAGE 
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