Prediction of Clinical Outcome in Patients with Idiopathic Thrombocytopenic Purpura by Evaluating Bone Marrow Clot CD20^+ B Lymphocytes and Morphological Changes of Megakaryocytes

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The pathology of B-lymphocytes in the bone marrow of patients with idiopathic thrombocytopenic purpura (ITP) has not been well described, even though B-lymphocytes may be involved in the etiology of ITP. We retrospectively reviewed the medical records of 73 ITP patients between January 1997 and June 2005 with platelet counts of < 50 x 10<SUP>9</SUP>/<I>L</I>. Bone marrow clots were available for pathological review in 56 patients who were classified into 3 groups based on the results of the bone marrow clot examination : Group A (21 patients) had increased CD20<SUP>+</SUP> lymphocytes (≧1% of nucleated cells) and megakaryocytes with morphologic changes ; Group B (21 patients) had morphologic changes but no increase in CD20<SUP>+</SUP> lymphocytes ; and Group C (14 patients) had neither morphologic changes nor increased CD20<SUP>+</SUP> lymphocytes. Multivariate analysis showed that, compared to Group A, Group B had a significant prognostic factor (<I>p</I> = 0.04 ; odds ratio, 6.65 ; 95% confidence interval, 1.09 to 40.54) for achieving complete response, while Group C had a significant prognostic factor for any treatment response (<I>p</I> = 0.04 ; odds ratio, 14.26 ; 95% confidence interval, 1.08 to 188.02). Thus, ITP patients can be classified with different clinical outcomes based on immunohistopathological examination of bone marrow clots. [<I>J Clin Exp Hematopathol 48(1) : 11-15, 200</I><I>8</I>]

収録刊行物

  • Journal of clinical and experimental hematopathology  

    Journal of clinical and experimental hematopathology 48(1), 11-15, 2008-05-01 

    The Japanese Society for Lymphoreticular Tissue Research

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各種コード

  • NII論文ID(NAID)
    10021246696
  • NII書誌ID(NCID)
    AA11556796
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13464280
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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