Different Histopathological Types of Orbital Lymphoma 16 Years after Systemic Follicular Lymphoma : Immunohistochemical and Immunogenetic Analyses of Two Cases

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著者

    • MATSUO Toshihiko
    • Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
    • ICHIMURA Kouichi
    • Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
    • SHINAGAWA Katsuji
    • Department of Hematology/Oncology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
    • YOSHINO Tadashi
    • Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

抄録

The purpose of this study is to show that the histopathological type of an orbital lymphoma can differ from the systemic follicular lymphoma that precedes it. A 44-year-old man (Patient #1) and a 50-year-old man (Patient #2) presented with generalized lymphadenopathy due to grade 1 follicular lymphoma proven on lymph node biopsy. Patient #1 was followed without treatment for 16 years when he developed a right orbital mass. Patient #2 underwent several courses of combination chemotherapy as well as radiation but relapsed. The second biopsy of the lymph node nine years later showed the same histopathological type of follicular lymphoma. He developed an orbital mass on the right side 16 years after the initial presentation. In Patient #1, excisional biopsy of the orbital masses showed extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). In Patient #2, biopsy revealed the orbital mass to be T-cell/histiocyte-rich diffuse large B-cell lymphoma. In Patient #1, when comparing the original lymph node biopsy to the orbital biopsy obtained years later, no evidence for clonality was noted by polymerase chain reaction. In Patient #2, the amplification by polymerase chain reaction of the immunoglobulin heavy chain gene rearrangement in the lymph node lesion and the orbital lesion gave rise to a single discrete band with the same DNA sequence except for five nucleotide changes, indicating the same clonality in the presence of genomic changes. In conclusion, orbital lymphomas can occur as a second lymphoma with a different histopathological type in the long-term follow-up of systemic lymphomas. The original and subsequent lymphomatous lesions may or may not share neoplastic cell clonality and all genomics. [<I>J Clin Exp Hematopathol 48(1) : 17-24, 2008</I>]

収録刊行物

  • Journal of clinical and experimental hematopathology  

    Journal of clinical and experimental hematopathology 48(1), 17-24, 2008-05-01 

    The Japanese Society for Lymphoreticular Tissue Research

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各種コード

  • NII論文ID(NAID)
    10021246715
  • NII書誌ID(NCID)
    AA11556796
  • 本文言語コード
    ENG
  • 資料種別
    NOT
  • ISSN
    13464280
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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