Clinicopathological analysis of patients with angioimmunoblastic T-cell lymphoma (AILT)

DOI Web Site PubMed 21 References
  • SAITO Akio
    Division of Internal Medicine, National Hospital Organization Nishigunma National Hospital
  • MIYAZAWA Yuri
    Division of Internal Medicine, National Hospital Organization Nishigunma National Hospital
  • ISODA Atsushi
    Division of Internal Medicine, National Hospital Organization Nishigunma National Hospital
  • HATSUMI Nahoko
    Division of Internal Medicine, National Hospital Organization Nishigunma National Hospital
  • MATSUMOTO Morio
    Division of Internal Medicine, National Hospital Organization Nishigunma National Hospital
  • KOJIMA Masaru
    Department of Pathology and Clinical Laboratories, Gunma Cancer Center Hospital
  • SAWAMURA Morio
    Division of Internal Medicine, National Hospital Organization Nishigunma National Hospital

Bibliographic Information

Other Title
  • 血管免疫芽球性Ｔ細胞リンパ腫（ＡＩＬＴ）の臨床病理学的検討
  • 臨床研究 血管免疫芽球性T細胞リンパ腫(AILT)の臨床病理学的検討
  • リンショウ ケンキュウ ケッカン メンエキ ガキュウセイ T サイボウ リンパシュ AILT ノ リンショウ ビョウリガクテキ ケントウ

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Abstract

We retrospectively analyzed the clinical course and prognosis of 11 patients with angioimmunoblastic T-cell Lymphoma (AILT). Median patient age was 62 years old (range 39 to 85). All patients were in clinical stage III or IV. Clinical features included B symptoms, hepatosplenomegaly, skin rushes, pleural effusion, ascites and polyclonal hypergammaglobulinemia. The disease can be classified into three categories based on histological findings: 3 cases of AILT with hyperplastic germinal centers, 4 cases of typical AILT, and 4 cases of AILT with numerous clear cells. As the initial therapy, 10 patients received combination chemotherapy and only 1 patient received autologous peripheral blood stem cell transplantation. Seven patients achieved CR and 4 showed PD. The response rate was 63% and the median survival time was 20 months. One patient survived in CR for 122 months. Patients with AILT demonstrating hyperplastic germinal centers and no bone marrow infiltration were able to achieve long-term survival. The survival time of AILT demonstrated a wide range. It was thought that further consideration of the prognostic factors and stratification was required.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 49 (2), 82-88, 2008

    The Japanese Society of Hematology

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