Cutaneous nontuberculous mycobacterial infection following cord blood stem cell transplantation

DOI Web Site PubMed 12 References
  • YANAGIMACHI Masakatsu
    Department of Pediatrics, Yokohama City University School of Medicine
  • GOTO Hiroaki
    Department of Pediatrics, Yokohama City University School of Medicine
  • YOKOSUKA Tomoko
    Department of Pediatrics, Yokohama City University School of Medicine
  • KAJIWARA Ryosuke
    Department of Pediatrics, Yokohama City University School of Medicine
  • FUJII Hisaki
    Department of Pediatrics, Yokohama City University School of Medicine
  • KUROKI Fumiko
    Department of Pediatrics, Yokohama City University School of Medicine
  • ITO Shuichi
    Department of Pediatrics, Yokohama City University School of Medicine
  • YOKOTA Shumpei
    Department of Pediatrics, Yokohama City University School of Medicine
  • TANIGUCHI Aiko
    Department of Dermatology, Yokohama City University School of Medicine
  • SHIGEHIRA Yuki
    Department of Dermatology, Yokohama City University School of Medicine
  • IKEZAWA Zenro
    Department of Dermatology, Yokohama City University School of Medicine
  • INAYAMA Yoshiaki
    Department of Pathology, Yokohama City University Hospital

Bibliographic Information

Other Title
  • 臍帯血移植後に発症した皮膚非結核性抗酸菌症
  • 症例報告 臍帯血移植後に発症した皮膚非結核性抗酸菌症
  • ショウレイ ホウコク サイタイケツ イショクゴ ニ ハッショウシタ ヒフ ヒケッカクセイ コウサンキンショウ

Search this article

Abstract

We describe a 4-year-old-girl with familial hemophagocytic lymphohistiocytosis (FHL) who developed disseminated cutaneous nontuberculous mycobacterial (NTM) infection after unrelated cord blood stem cell transplantation (uCBSCT). After transplantation, the patient developed steroid-refractory acute graft-versus-host disease, and was given methylprednisolone, cyclosporin and mycophenolate mofetil. Six months after uCBSCT, cutaneous lesions that looked like insect bites appeared and spread widely over the thighs. NTM infection was diagnosed by skin biopsy although no organism could be identified. Minocycline (MINO) and sulfamethoxazole/trimethoprim (ST) were administered. However, the cutaneous disease followed a course of remissions and exacerbations. One month after the skin biopsy, mycobacterium chelonae was detected by bacteriological culture of abscess drainage. Ten months after uCBSCT, the cutaneous lesions quickly progressed and the inguinal lymph nodes became enlarged and painful. Then the antibiotics were switched from MINO and ST to amikacin and clarithromycin (CAM) based on the results of mycobacterial susceptibility test. The cutaneous lesions gradually improved after continuous administration of CAM. Cutaneous NTM infection is rare, but it may occur in immunocompromised patients after SCT.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 49 (2), 99-103, 2008

    The Japanese Society of Hematology

References(12)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top