<i>ATIC-ALK</i>-positive anaplastic large cell lymphoma: a case report and review of the literature
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- MATSUBARA Kousaku
- Department of Pediatrics, Nishi-Kobe Medical Center
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- TANAKA Takayuki
- Department of Pediatrics, Nishi-Kobe Medical Center
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- TAKI Tomohiko
- Department of Molecular Laboratory Medicine, Kyoto Prefectural University of Medicine, Graduate School of Medicine Science
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- NAKAGAWA Atsuko
- Department of Pathology, National Research Institute for Child Health and Development
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- NIGAMI Hiroyuki
- Department of Pediatrics, Nishi-Kobe Medical Center
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- TAMURA Akihiro
- Department of Pediatrics, Nishi-Kobe Medical Center
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- FUKAYA Takashi
- Department of Pediatrics, Nishi-Kobe Medical Center
Bibliographic Information
- Other Title
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- <i>ATIC-ALK</i>陽性未分化大細胞型リンパ腫
- 症例報告 ATIC-ALK陽性未分化大細胞型リンパ腫--症例報告と文献的検討
- ショウレイ ホウコク ATIC ALK ヨウセイ ミブンカ ダイサイボウガタ リンパシュ ショウレイ ホウコク ト ブンケンテキ ケントウ
- —症例報告と文献的検討—
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Abstract
We report a 10-year-old girl with ATIC-anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL). She presented with inguinal, axillary, and paraaortic lymph node swellings that showed spontaneous regression over a 3-month period, followed by recurrence after an interval of 8 months. Radiological and clinical findings indicated Ann Arbor stage IIIA. Pathological findings showed that staining of ALK was restricted to the cytoplasm of ALCL cells. ATIC-ALK chimeric transcripts were detected by reverse transcriptase polymerase chain reaction. The patient was assigned to the standard risk group proposed by the international multicenter study for pediatric ALCL, ALCL99. The patient responded well to the treatment and remained in complete remission for more than 26 months. To date, 7 genes have been identified as a fusion partner of ALK, with the highest frequency in nucleophosmin (NPM). Little is known about the clinical implications of subtypes of ALCL harboring each of the 7 fusion genes, especially those of variant fusion genes other than NPM-ALK. In this paper, we review 9 patients with ATIC-ALK-positive ALCL in the literature in addition to discussing our patient. In eight of these 10 cases, disease occurred within the first three decades. Five of 6 cases that were followed continuously remained in complete remission.
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 49 (5), 325-330, 2008
The Japanese Society of Hematology
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Keywords
Details 詳細情報について
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- CRID
- 1390001205030544768
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- NII Article ID
- 10021257799
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- NII Book ID
- AN00252940
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- COI
- 1:STN:280:DC%2BD1cvgsVKrsg%3D%3D
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- ISSN
- 18820824
- 04851439
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- NDL BIB ID
- 9671796
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- PubMed
- 18572809
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed