日本人特有の血栓性素因 : プロテインS, プロテインC分子異常 Japanese Thrombophilia : Protein S/Protein C Anomaly as the major risk factor for Japanese Thrombophilia

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著者

    • 濱崎 直孝 HAMASAKI Naotaka
    • 九州大学大学院医学研究院臨床検査医学 Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences Kyushu University

抄録

Coagulation factor V Leiden has not been detected in Japanese patients suffering from thromboses. We have performed a systematic investigation to find out genetic risk factors for thromboses in Japanese population. Routine coagulation and fibrinolysis tests were performed to determine the activities of protein S/C, antithrombin, plasminogen, heparin cofactor II and fibrinogen. Gene analyses were performed In thrombotic patients having the low activities of these factors and the constitutional background of Japanese thrombotic patients was systematically examined from the gene analyses. <br>Our study indicates that the frequency (19/85=0.22) of mutations of protein S gene in the Japanese patients was 5-10 times higher than that of mutations of protein S gene in Caucasian patients, and the frequency (8/85=0.09) of mutations of protein C gene was almost three times higher than that of Caucasian patients, suggesting that Protein S/Protein C Anomaly is the major risk factor for Japanese thrombophilia. It is interesting to note that the frequency of factor V Leiden (20-50%) in Caucasian deep vein thrombosis patients is similar to that (30%) of heterozygous gene mutations of the protein S/protein C anticoagulation system in Japanese deep vein thrombosis patients. Protein S<SUB>Tokushima</SUB> (K155E) is another risk factor for deep vein thrombosis in Japanese population.

収録刊行物

  • 日本血栓止血学会誌 = The Journal of Japanese Society on Thrombosis and Hemostasis  

    日本血栓止血学会誌 = The Journal of Japanese Society on Thrombosis and Hemostasis 17(2), 136-143, 2006-04-01 

    The Japanese Society on Thrombosis and Hemostasis

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各種コード

  • NII論文ID(NAID)
    10021258530
  • NII書誌ID(NCID)
    AN10353762
  • 本文言語コード
    JPN
  • 資料種別
    SHO
  • ISSN
    09157441
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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