Influence of Adiponectin Gene Polymorphism SNP276 (G/T) on Adiponectin in Response to Exercise Training
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- HUANG Hu
- Graduate School of Comprehensive Human Sciences, University of Tsukuba
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- TADA IIDA Kaoruko
- Graduate School of Comprehensive Human Sciences, University of Tsukuba
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- MURAKAMI Haruka
- Graduate School of Comprehensive Human Sciences, University of Tsukuba
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- SAITO Yoko
- Graduate School of Comprehensive Human Sciences, University of Tsukuba
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- OTSUKI Takeshi
- Center for Tsukuba Advanced Research Alliance, University of Tsukuba
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- IEMITSU Motoyuki
- Center for Tsukuba Advanced Research Alliance, University of Tsukuba
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- MAEDA Seiji
- Center for Tsukuba Advanced Research Alliance, University of Tsukuba
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- SONE Hirohito
- Faculty of Human Life and Environmental Sciences, Ochanomizu University
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- KUNO Shinya
- Graduate School of Comprehensive Human Sciences, University of Tsukuba
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- AJISAKA Ryuichi
- Graduate School of Comprehensive Human Sciences, University of Tsukuba
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Adiponectin is an adipocytokine that is involved in insulin sensitivity. The adiponectin gene contains a single nucleotide polymorphism (SNP) at position 276 (G/T). The GG genotype of SNP276 (G/T) is associated with lower plasma adiponectin levels and a higher insulin resistance index. Therefore, we examined the influence of SNP276 (G/T) on the plasma level of adiponectin in response to exercise training. Thirty healthy Japanese (M12/F18; 56 to 79 years old) performed both resistance and endurance training, 5 times a week for 6 months. The work rate per kg of weight at double-product break-point (DPBP) was measured. Blood samples were obtained before and after the experiment. Plasma concentrations of adiponectin, HbA1c, insulin, glucose, total, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) cholesterol, and triglyceride were measured. Genotypes of SNP276 were specified. Student's t-test for paired values and unpaired values was used. After the 6-month training period, the work rate per kg of weight at DPBP and the plasma HDL-cholesterol level were significantly improved (P<0.05), while no change was observed in the total plasma adiponectin level. However, the plasma adiponectin level in those with the GT + TT genotype had significantly increased (P<0.05). Additionally, the degree of the decrease in the HOMA-R level was significantly greater in the subjects with the GT + TT genotype than those with the GG genotype (p<0.05). Our results suggest that subjects with the genotype GT + TT at SNP276 (G/T) have a greater adiponectin-related response to exercise training than those with the GG genotype.<br>
収録刊行物
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- Endocrine Journal
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Endocrine Journal 54 (6), 879-886, 2007
一般社団法人 日本内分泌学会
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詳細情報 詳細情報について
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- CRID
- 1390282681275744384
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- NII論文ID
- 10021263616
- 130004443338
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- NII書誌ID
- AA10901436
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- ISSN
- 13484540
- 09188959
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可