Influence of Adiponectin Gene Polymorphism SNP276 (G/T) on Adiponectin in Response to Exercise Training

• HUANG Hu

  Graduate School of Comprehensive Human Sciences, University of Tsukuba

• TADA IIDA Kaoruko

  Graduate School of Comprehensive Human Sciences, University of Tsukuba

• MURAKAMI Haruka

  Graduate School of Comprehensive Human Sciences, University of Tsukuba

• SAITO Yoko

  Graduate School of Comprehensive Human Sciences, University of Tsukuba

• OTSUKI Takeshi

  Center for Tsukuba Advanced Research Alliance, University of Tsukuba

• IEMITSU Motoyuki

  Center for Tsukuba Advanced Research Alliance, University of Tsukuba

• MAEDA Seiji

  Center for Tsukuba Advanced Research Alliance, University of Tsukuba

• SONE Hirohito

  Faculty of Human Life and Environmental Sciences, Ochanomizu University

• KUNO Shinya

  Graduate School of Comprehensive Human Sciences, University of Tsukuba

• AJISAKA Ryuichi

  Graduate School of Comprehensive Human Sciences, University of Tsukuba

抄録

Adiponectin is an adipocytokine that is involved in insulin sensitivity. The adiponectin gene contains a single nucleotide polymorphism (SNP) at position 276 (G/T). The GG genotype of SNP276 (G/T) is associated with lower plasma adiponectin levels and a higher insulin resistance index. Therefore, we examined the influence of SNP276 (G/T) on the plasma level of adiponectin in response to exercise training. Thirty healthy Japanese (M12/F18; 56 to 79 years old) performed both resistance and endurance training, 5 times a week for 6 months. The work rate per kg of weight at double-product break-point (DPBP) was measured. Blood samples were obtained before and after the experiment. Plasma concentrations of adiponectin, HbA1c, insulin, glucose, total, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) cholesterol, and triglyceride were measured. Genotypes of SNP276 were specified. Student's t-test for paired values and unpaired values was used. After the 6-month training period, the work rate per kg of weight at DPBP and the plasma HDL-cholesterol level were significantly improved (P<0.05), while no change was observed in the total plasma adiponectin level. However, the plasma adiponectin level in those with the GT + TT genotype had significantly increased (P<0.05). Additionally, the degree of the decrease in the HOMA-R level was significantly greater in the subjects with the GT + TT genotype than those with the GG genotype (p<0.05). Our results suggest that subjects with the genotype GT + TT at SNP276 (G/T) have a greater adiponectin-related response to exercise training than those with the GG genotype.<br>

収録刊行物

• Endocrine Journal

  Endocrine Journal 54 (6), 879-886, 2007

  一般社団法人 日本内分泌学会

キーワード

• Adiponectin
• Genotype
• Insulin sensitivity
• Exercise training

詳細情報

• CRID: 1390282681275744384
• NII論文ID: 10021263616
• NII論文ID: 130004443338
• NII書誌ID: AA10901436
• DOI: 10.1507/endocrj.k06-146
• ISSN: 13484540
• ISSN: 09188959
• Web Site: http://www.jstage.jst.go.jp/article/endocrj/54/6/54_K06-146/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008213588
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可