Ratio of Serum IgG3 to Total IgG Concentration and Goiter Size Are Independent Factors in Intractability of Graves' Disease

• SANTOH Tomoko

  Department of Biomedical Informatics, Division of Health Science, Osaka University Graduate School of Medicine

• WATANABE Mikio

  Department of Biomedical Informatics, Division of Health Science, Osaka University Graduate School of Medicine

• KURODA Shoko

  Department of Biomedical Informatics, Division of Health Science, Osaka University Graduate School of Medicine

• UEDA Daishi

  Department of Biomedical Informatics, Division of Health Science, Osaka University Graduate School of Medicine

• IWATANI Yoshinori

  Department of Biomedical Informatics, Division of Health Science, Osaka University Graduate School of Medicine

抄録

Peripheral immunoglobulin (Ig) G₃-secreting cells and serum concentrations of interleukin (IL)-10, a class-switching factor to IgG₃-secreting cells, increase in patients with intractable Graves' disease (GD). However, they are not practical for laboratory tests. To find more stable and easily detectable markers of disease intractability or disease severity in patients with GD or Hashimoto's disease (HD), we examined the serum concentration of IgG₃ in 58 euthyroid GD patients who had been undergoing antithyroid drug treatment for more than 5 years but still must continue drug treatment to maintain a euthyroid state (intractable GD), 26 GD patients who had maintained a euthyroid state for more than 2 years without any treatment (GD in remission), 20 untreated, thyrotoxic GD patients, 40 euthyroid HD patients treated with thyroxine (5 men and 35 women), 13 untreated, euthyroid HD patients, and 39 healthy volunteers. Serum concentrations of IgG₃ increased in euthyroid patients with intractable GD and in those with GD in remission, but serum concentrations of IgG were not altered. The ratio of serum concentrations of IgG₃ to total IgG (IgG₃/IgG ratio) was higher in euthyroid patients with intractable GD than in those with GD in remission. Multiple logistic-regression analysis demonstrated that IgG₃/IgG ratio and goiter size were independent factors in disease intractability of GD patients. These results suggest that IgG₃/IgG ratio and goiter size may be used as independent markers associated with GD intractability.<br>

収録刊行物

• Endocrine Journal

  Endocrine Journal 54 (6), 887-894, 2007

  一般社団法人 日本内分泌学会

キーワード

• Goiter
• IgG₃
• Disease intractability
• Graves' disease

詳細情報

• CRID: 1390001206299032832
• NII論文ID: 10021263651
• NII論文ID: 130004443339
• NII書誌ID: AA10901436
• DOI: 10.1507/endocrj.k07-005
• ISSN: 13484540
• ISSN: 09188959
• Web Site: http://www.jstage.jst.go.jp/article/endocrj/54/6/54_K07-005/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008213589
• 本文言語コード: en
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