Serum Levels of Ghrelin, Leptin, IGF-I, IGFBP-3, Insulin, Thyroid Hormones and Cortisol in Prepubertal Children with Iron Deficiency

DOI Web Site 被引用文献3件 参考文献53件
  • ISGUVEN Pinar
    Ministry of Health Istanbul Goztepe Education and Investigation Hospital, Department of Pediatric Endocrinology
  • ARSLANOGLU Ilknur
    Ministry of Health Istanbul Goztepe Education and Investigation Hospital, Department of Pediatric Endocrinology
  • EROL Melih
    Ministry of Health Istanbul Goztepe Education and Investigation Hospital, Department of Pediatric Endocrinology
  • YILDIZ Metin
    Ministry of Health Istanbul Goztepe Education and Investigation Hospital, Department of Pediatric Endocrinology
  • ADAL Erdal
    Ministry of Health Istanbul Goztepe Education and Investigation Hospital, Department of Pediatric Endocrinology
  • ERGUVEN Muferret
    Ministry of Health Istanbul Goztepe Education and Investigation Hospital, Department of Pediatric Endocrinology

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The aim of the present study is to investigate possible alterations in ghrelin and other hormone levels related to appetite and somatic growth in children with iron deficiency anemia. Twenty-five patients and 25 healthy controls that were prepubertal and within normal limits regarding height and BMI standard deviation scores were recruited. Ghrelin, leptin, IGF-I, IGFBP-3, insulin, thyroid hormones and cortisol levels were studied. Ghrelin, insulin and IGF-I levels were significantly low in the study group (ghrelin 13.58 ± 16.32 vs. 35.39 ± 23.69 ng/ml, p<.001; insulin 3.41 ± 2.42 vs. 5.67 ± 1.09 mU/ml, p = .008 and IGF-I 126.94 ± 92.82 vs. 203 ± 105.1 ng/ml, p = .015). We concluded that low ghrelin and insulin levels might be causes of the appetite loss in iron deficiency and as a result of appetite loss and undernutrition as well as by direct effects they might be related with growth retardation, which could be also influenced by low IGF-I levels.<br>

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  • Endocrine Journal

    Endocrine Journal 54 (6), 985-990, 2007

    一般社団法人 日本内分泌学会

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