Actions and Mode of Actions of FGF19 Subfamily Members

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著者

    • FUKUMOTO SEIJI
    • Division of Nephrology & Endocrinology, Department of Medicine, University of Tokyo Hospital

抄録

Fibroblast growth factors (FGFs) are humoral factors with diverse biological functions. While most FGFs were shown to work as local factors regulating cell growth and differentiation, recent investigations indicated that FGF19 subfamily members, FGF15/19, FGF21 and FGF23 work as systemic factors. FGF15/19 produced by intestine inhibits bile acid synthesis and FGF21from liver is involved in carbohydrate and lipid metabolism. In addition, FGF23 was shown to be produced by bone and regulate phosphate and vitamin D metabolism. Furthermore, these FGFs require klotho or βklotho for their actions in addition to canonical FGF receptors. It is possible that these FGFs together with their receptor systems might be targets for novel therapeutic measures in the future.<br>

収録刊行物

  • Endocrine journal  

    Endocrine journal 55(1), 23-31, 2008-02-01 

    The Japan Endocrine Society

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各種コード

  • NII論文ID(NAID)
    10021264366
  • NII書誌ID(NCID)
    AA10901436
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    09188959
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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