Actions and Mode of Actions of FGF19 Subfamily Members

• FUKUMOTO Seiji

  Division of Nephrology & Endocrinology, Department of Medicine, University of Tokyo Hospital

Abstract

Fibroblast growth factors (FGFs) are humoral factors with diverse biological functions. While most FGFs were shown to work as local factors regulating cell growth and differentiation, recent investigations indicated that FGF19 subfamily members, FGF15/19, FGF21 and FGF23 work as systemic factors. FGF15/19 produced by intestine inhibits bile acid synthesis and FGF21from liver is involved in carbohydrate and lipid metabolism. In addition, FGF23 was shown to be produced by bone and regulate phosphate and vitamin D metabolism. Furthermore, these FGFs require klotho or βklotho for their actions in addition to canonical FGF receptors. It is possible that these FGFs together with their receptor systems might be targets for novel therapeutic measures in the future.<br>

Journal

• Endocrine Journal

  Endocrine Journal 55 (1), 23-31, 2008

  The Japan Endocrine Society

Keywords

• Hypophosphatemia
• Hyperphosphatemia
• Klotho
• FGF

Details

• CRID: 1390282681275688576
• NII Article ID: 10021264366
• NII Book ID: AA10901436
• DOI: 10.1507/endocrj.kr07e-002
• COI: 1:STN:280:DC%2BD1c7otFChtQ%3D%3D
• ISSN: 13484540
• ISSN: 09188959
• PubMed: 17878606
• Web Site: http://www.jstage.jst.go.jp/article/endocrj/55/1/55_KR07E-002/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008175193
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed