Estrogen Suppresses Retinaldehyde Dehydrogenase 1 Expression in the Anterior Pituitary Glands of Female Rats

DOI Web Site 被引用文献7件 参考文献33件
  • FUJIWARA Ken
    Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine
  • DAVAADASH Bulgan
    Department of Microbiology and Immunology, Health Sciences University of Mongolia, School of Biomedicine
  • KIKUCHI Motoshi
    Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine
  • TAKIGAMI Shu
    Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine
  • YASHIRO Takashi
    Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine

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Retinoic acid (RA) plays a critical role in cell growth and tissue development. RA is also a regulating factor of pituitary function. RA is synthesized from retinoids through oxidation processes. The oxidation of retinal to RA is catalyzed by the retinaldehyde dehydrogenases (RALDHs), including RALDH1, RALDH2 and RALDH3. Recently, we demonstrated that RALDH1 is expressed in the anterior pituitary glands of adult male rats. However, the expression of RALDH1 in the female pituitary gland and the regulation of RALDH1 expression have not been determined. Therefore, we examined the expression of RALDH1 mRNA in the pituitary glands of adult female rats. By in situ hybridization with digoxigenin-labeled cRNA probes and quantitative real-time PCR analysis, we found that the expression level of RALDH1 was significantly lower in estrus as compared to proestrus, metestrus and diestrus. RALDH1 mRNA levels increased after ovariectomy and decreased remarkably after a 1-week treatment with 17β-estradiol implants. Estradiol (0.01-100 μg per rat) dose-dependently decreased the expression of RALDH1 in the pituitary glands after 24 hours of subcutaneous administration. These results clearly show that RALDH1 mRNA expression is suppressed by estrogen. We speculate that the generation of RA is regulated by estrogen and that RA plays a role in the estrus cycle through paracrine and/or autocrine mechanisms in the anterior pituitary gland of female rats.<br>

収録刊行物

  • Endocrine Journal

    Endocrine Journal 55 (1), 91-96, 2008

    一般社団法人 日本内分泌学会

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