Subclinical Hypercortisolism in Hospitalized Patients with Type 2 Diabetes Mellitus

• TANIGUCHI Takao

  Department of Internal Medicine, Ohtsu Red Cross Hospital

• HAMASAKI Akihiro

  Department of Diabetes and Clinical Nutrition, Kyoto University Faculty of Medicine

• OKAMOTO Motozumi

  Department of Internal Medicine, Ohtsu Red Cross Hospital

抄録

Pre(sub)clinical Cushing's disease is a recently described entity defined by the autonomous secretion of ACTH and the absence of a cushingoid appearance. We screened 77 hospitalized patients with diabetes mellitus for subclinical hypercortisolism and detected pre(sub)clinical Cushing's disease in 2 (2.6%) of them. In both patients, transsphenoidal surgery was performed and a microadenoma was removed. Their metabolic clearance rate of glucose measured by a glucose clamp study, an index of insulin sensitivity, significantly improved after surgery. Our results indicate that screening for subclinical hypercortisolism in diabetic patients might be useful, as surgery improves glucose tolerance and insulin sensitivity.<br>

収録刊行物

• Endocrine Journal

  Endocrine Journal 55 (2), 429-432, 2008

  一般社団法人 日本内分泌学会

キーワード

• Subclinical hypercortisolism
• Pre(sub)clinical Cushing's disease
• Diabetes mellitus
• Insulin sensitivity
• Glucose clamp study

詳細情報

• CRID: 1390001206298854144
• NII論文ID: 10021265985
• NII論文ID: 130004443410
• NII書誌ID: AA10901436
• DOI: 10.1507/endocrj.k07e-045
• ISSN: 13484540
• ISSN: 09188959
• Web Site: http://www.jstage.jst.go.jp/article/endocrj/55/2/55_K07E-045/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008234300
• 本文言語コード: en
• データソース種別:
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  • Crossref
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