A C/T Polymorphism in CD40 Gene is Not Associated with Susceptibility and Phenotype of Graves' Disease in Taiwanese

DOI Web Site 被引用文献2件 参考文献49件
  • HSIAO Jeng-Yueh
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital
  • TIEN Kai-Jen
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chi-Mei Medical Center
  • HSIAO Cheng-Ting
    Department of Emergency Medicine, Chang Gung Memorial Hospital Chang Gung University College of Medicine
  • HSIEH Ming-Chia
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital

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A single nucleotide polymorphism (SNP) located at position-1 in the Kozak sequence of the CD40 gene has been associated with the development of GD in Caucasian and Koreans. This study investigated possible associated between CD40 SNP and the development of GD in a Taiwanese population. To do this, we enrolled 215 Taiwanese patients with GD and 141 controls from the Endocrine Clinic of Kaohsiung Medical University Hospital. This study investigated the association between gene polymorphism and relapse of hyperthyroidism after the discontinuation of medication in three GD patient groups based on time to relapse and a control group, and compared clinical and laboratory data of patients regrouped in three CD40 SNP genotypes. No significant difference in allele or CD40 SNP genotype frequency was observed between patients with GD and control subjects (P = 0.859 and P = 0.959, respectively). Furthermore, we analyzed the distribution of CD40 genotypes and three groups based on time to relapse after drug withdrawal. The cutoff points were 9 months, 9 months to 3 years, and more than 3 yr in subgroups of patients with GD divided by clinical and laboratory variables. Although no significant genotype-phenotype associations were found, the T allele and TT genotype frequency was significantly smaller in GD patients who had developed the disease before 35 years old than those who developed it after 35 years old (x 2 = 6.272, P = 0.043) (TT + CT v.s. CC, x 2 = 4.951, P = 0.030). These findings suggest that this CD40 gene polymorphism is not associated with GD in Taiwan and is, therefore, not contributing to susceptibility to the disease there.<br>

収録刊行物

  • Endocrine Journal

    Endocrine Journal 55 (3), 477-484, 2008

    一般社団法人 日本内分泌学会

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