Glycated Albumin is a Better Indicator for Glucose Excursion than Glycated Hemoglobin in Type 1 and Type 2 Diabetes

• YOSHIUCHI Kazutomi

  Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine

• MATSUHISA Munehide

  Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine

• KATAKAMI Naoto

  Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine

• NAKATANI Yoshihisa

  Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine

• SAKAMOTO Kenya

  Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine

• MATSUOKA Takaaki

  Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine

• UMAYAHARA Yutaka

  Department of Internal Medicine, Osaka Police Hospital

• KOSUGI Keisuke

  Department of Internal Medicine, Osaka Police Hospital

• KANETO Hideaki

  Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine

• YAMASAKI Yoshimitsu

  Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine

• HORI Masatsugu

  Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine

抄録

To determine the impact of blood glucose profile, involving fluctuation and excursion of blood glucose levels, on glycated proteins, we evaluated the association among the daily profile of blood glucose, and glycated albumin (GA) and HbA1c levels in patients with type 1 diabetes (n = 93) and type 2 diabetes (n = 75). GA levels were strongly correlated with HbA1c levels in type 1 (r = 0.85, P<0.0001) and type 2 diabetes (r = 0.61, P<0.0001), respectively. HbA1c levels were similar between patients with type 1 and type 2 diabetes, while GA levels were significantly higher in type 1 diabetes. Thus the ratio of GA levels to HbA1c levels was significantly higher in type 1 diabetes than that in type 2 diabetes (3.32 0.36 vs. 2.89 0.44, p<0.001). The degrees of GA levels and HbA1c levels correlated with maximum and mean blood glucose levels in patients with type 1 and type 2 diabetes. Stepwise multivariate analysis revealed that GA levels independently correlated with maximum blood glucose levels in type 1 diabetes (F = 43.34, P<0.001) and type 2 diabetes (F = 41.57, P<0.001). HbA1c levels also independently correlated with maximum blood glucose levels in type 1 diabetes (F = 34.78, P<0.001), as well as being correlated with mean blood glucose levels in type 2 diabetes (F = 11.28, P<0.001). In summary, GA could be a better marker for glycemic control than glycated hemoglobin in diabetic patients, especially for evaluating glycemic excursion, which is considered to be a major cause of diabetic angiopathy.<br>

収録刊行物

• Endocrine Journal

  Endocrine Journal 55 (3), 503-507, 2008

  一般社団法人 日本内分泌学会

キーワード

• Glycated albumin
• HbA1c
• Glycemic excursion

詳細情報

• CRID: 1390282681276171136
• NII論文ID: 10021266405
• NII書誌ID: AA10901436
• DOI: 10.1507/endocrj.k07e-089
• COI: 1:STN:280:DC%2BD1cvitlCmsw%3D%3D
• ISSN: 13484540
• ISSN: 09188959
• PubMed: 18445997
• Web Site: http://www.jstage.jst.go.jp/article/endocrj/55/3/55_K07E-089/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008285029
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可