Glycated Albumin is a Better Indicator for Glucose Excursion than Glycated Hemoglobin in Type 1 and Type 2 Diabetes

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著者

    • YOSHIUCHI KAZUTOMI
    • Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine
    • MATSUHISA MUNEHIDE
    • Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine
    • KATAKAMI NAOTO
    • Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine
    • NAKATANI YOSHIHISA
    • Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine
    • SAKAMOTO KENYA
    • Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine
    • MATSUOKA TAKAAKI
    • Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine
    • KANETO HIDEAKI
    • Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine
    • YAMASAKI YOSHIMITSU
    • Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine
    • HORI MASATSUGU
    • Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine

抄録

To determine the impact of blood glucose profile, involving fluctuation and excursion of blood glucose levels, on glycated proteins, we evaluated the association among the daily profile of blood glucose, and glycated albumin (GA) and HbA1c levels in patients with type 1 diabetes (n = 93) and type 2 diabetes (n = 75). GA levels were strongly correlated with HbA1c levels in type 1 (r = 0.85, P<0.0001) and type 2 diabetes (r = 0.61, P<0.0001), respectively. HbA1c levels were similar between patients with type 1 and type 2 diabetes, while GA levels were significantly higher in type 1 diabetes. Thus the ratio of GA levels to HbA1c levels was significantly higher in type 1 diabetes than that in type 2 diabetes (3.32 0.36 vs. 2.89 0.44, p<0.001). The degrees of GA levels and HbA1c levels correlated with maximum and mean blood glucose levels in patients with type 1 and type 2 diabetes. Stepwise multivariate analysis revealed that GA levels independently correlated with maximum blood glucose levels in type 1 diabetes (F = 43.34, P<0.001) and type 2 diabetes (F = 41.57, P<0.001). HbA1c levels also independently correlated with maximum blood glucose levels in type 1 diabetes (F = 34.78, P<0.001), as well as being correlated with mean blood glucose levels in type 2 diabetes (F = 11.28, P<0.001). In summary, GA could be a better marker for glycemic control than glycated hemoglobin in diabetic patients, especially for evaluating glycemic excursion, which is considered to be a major cause of diabetic angiopathy.<br>

収録刊行物

  • Endocrine journal  

    Endocrine journal 55(3), 503-507, 2008-06-01 

    The Japan Endocrine Society

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各種コード

  • NII論文ID(NAID)
    10021266405
  • NII書誌ID(NCID)
    AA10901436
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09188959
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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