A Case of Fulminant Type 1 Diabetes Associated With Significant Elevation of Mumps Titers

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  • GOTO Atsushi
    Department of Diabetes and Metabolic Medicine, International Medical Center of Japan
  • TAKAHASHI Yoshihiko
    Department of Diabetes and Metabolic Medicine, International Medical Center of Japan
  • KISHIMOTO Miyako
    Department of Diabetes and Metabolic Medicine, International Medical Center of Japan
  • NAKAJIMA Yoshifumi
    Department of Diabetes and Metabolic Medicine, International Medical Center of Japan
  • NAKANISHI Koji
    Department of General Internal Medicine and Metabolism, Toranomon Hospital
  • KAJIO Hiroshi
    Department of Diabetes and Metabolic Medicine, International Medical Center of Japan
  • NODA Mitsuhiko
    Department of Diabetes and Metabolic Medicine, International Medical Center of Japan

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抄録

Type 1 diabetes mellitus is classified as either autoimmune or idiopathic. Fulminant type 1 diabetes was originally reported as a subtype of idiopathic type 1 diabetes. Though involvement of viral infections has been suggested as a triggering mechanism, its pathogenesis remains unknown. Here, we present a case of fulminant type 1 diabetes associated with significant elevation of mumps titers. A 56-year-old Japanese man had suffered from nausea and generalized fatigue for two days before being transferred to our hospital in a confused state. Findings on admission revealed a high blood glucose level, near-normal HbA1c level, metabolic acidosis, and increased urinary ketone levels. Serum tests for islet-associated autoantibodies were negative. The serum, urinary C-peptide levels and the result of glucagon test indicated severe impairment of insulin secretion. These results were compatible with the diagnosis of fulminant type 1 diabetes. Also, he was suspected as having mumps infection on the basis of serological testing. These findings suggest that fulminant type 1 diabetes developed after mumps virus infection in our case. To the best of our knowledge, no other report has indicated an association between a recent mumps infection and the onset of fulminant type 1 diabetes. This case suggests an association between fulminant type 1 diabetes and mumps virus infection.<br>

収録刊行物

  • Endocrine Journal

    Endocrine Journal 55 (3), 561-564, 2008

    一般社団法人 日本内分泌学会

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