Infliximab が有効であったシクロスポリン抵抗性難治性潰瘍性大腸炎の1例  [in Japanese] A case of ulcerative colitis refractory to intravenous cyclosporine therapy successfully treated with infliximab  [in Japanese]

Access this Article

Search this Article



症例は26歳女性.潰瘍性大腸炎(UC)再燃のため当科入院となった.プレドニゾロンにより治療されたが改善なく,ステロイド抵抗性難治性UCと診断された.シクロスポリン持続静注療法などの治療を行ったが効果を認めなかったため,Infliximab 5mg/kgを計画的に投与した.初回投与より症状の改善を認め12週後に緩解を得た.Infliximabは難治性UCの治療に有効である可能性が示唆された.<br>

A 26-year-old woman was admitted to our hospital with relapse of ulcerative colitis (UC). We diagnosed it as a refractory UC because intravenous corticosteroid therapy had no effect. Intravenous cyclosporine therapy and other conventional therapies did not lead to remission. Then the possibility of infliximab was discussed with the patient and her parents and treatment with infliximab was started. Infliximab was infused intravenously at a dose of 5mg per kilograms of body weight. Immediately after the first infusion, clinical symptoms improved, and clinical remission was achieved within 12 weeks. It is suggested that infliximab can be effective for refractory UC. <br>


  • Nippon Shokakibyo Gakkai Zasshi  

    Nippon Shokakibyo Gakkai Zasshi 105(5), 679-685, 2008-05-05 

    The Japanese Society of Gastroenterology

References:  19

You must have a user ID to see the references.If you already have a user ID, please click "Login" to access the info.New users can click "Sign Up" to register for an user ID.


Page Top