出血を繰り返す十二指腸潰瘍を契機に診断された後天性血友病Ａの１例

• 村田 篤彦

  麻生飯塚病院消化器内科

• 赤星 和也

  麻生飯塚病院消化器内科

• 中村 和彦

  九州大学大学院医学研究院病態制御内科学

書誌事項

タイトル別名

• ACQUIRED HEMOPHILIA A DISCOVERED WITH A HEMORRHAGIC DUODENAL ULCER THAT HAD DIFFICULTY WITH ENDOSCOPIC HEMOSTASIS, REPORT A CASE

抄録

A 77-year-old woman was admitted to our hospital because of a hemorrhagic duodenal ulcer that had difficulty with endoscopic hemostasis and hemorrhage from right subclavian vein in which was inserted a central venous catheter. Coagulation tests showed a great prolongation of activated partial thromboplastin time (APTT) on admission . After admission, severe bleeding from the ulcer appeared, we performed endoscopic therapy by hypertonic saline epinephrine injection. Hemorrhage from right subclavian vein was stopped by astriction. Laboratory studies showed an extremely low factor uG activity and the presence of a very high titer factor uG inhibitor. She was diagnosed as acquired hemophilia A, and treated with oral prednisone, cyclophosphamide and intravenous methylprednisolone pulse therapy. After treat ment, activated partial thromboplastin time normalized and factor uG inhibitor disappeared . In case of gastrointestinal bleeding that had difficulty with endoscopic hemostasis, we should pay attention to the possibility of acquired hemophilia A .

収録刊行物

• 日本消化器内視鏡学会雑誌

  日本消化器内視鏡学会雑誌 50 (2), 217-222, 2008

  一般社団法人 日本消化器内視鏡学会

キーワード

• 後天性血友病A
• 抗第VIII凝固因子抗体
• 十二指腸潰瘍

詳細情報

• CRID: 1390001204220103168
• NII論文ID: 130004255159
• NII論文ID: 10021272094
• NII書誌ID: AN00192102
• DOI: 10.11280/gee1973b.50.217
• ISSN: 18845738
• ISSN: 03871207
• Web Site: https://search.jamas.or.jp/link/ui/2008174942
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可