Clinical Significance of Serum and Urinary Cystatin-C Levels in Diabetic Patients
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- Ishimaru Yasuaki
- Internal Medicine, Ishimaru Hospital
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- Imai Tomihiko
- Internal Medicine, Ishimaru Hospital
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- Gotoh Akiko
- Research & Development Division, Kyoto Medical Science Laboratory
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- Uchida Kazuo
- Research & Development Division, Kyoto Medical Science Laboratory
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- Nakamura Takahiro
- Internal Medicine, Ishimaru Hospital
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- Saito Takae
- Internal Medicine, Ishimaru Hospital
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- Satoh Fumiko
- Internal Medicine, Ishimaru Hospital
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- Ohshima Yukari
- Internal Medicine, Ishimaru Hospital
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- Isoyama Ai
- Department of Endocrinology and Diabetes, School of Medicine, Saitama Medical University
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- Katayama Shigehiro
- Department of Endocrinology and Diabetes, School of Medicine, Saitama Medical University
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- Ishimaru Yasuyo
- Internal Medicine, Ishimaru Hospital
Bibliographic Information
- Other Title
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- 2型糖尿病患者における血清,および尿中Cystatin-Cの検討
- 2ガタ トウニョウビョウ カンジャ ニ オケル ケッセイ オヨビ ニョウ チュウ Cystatin C ノ ケントウ
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Abstract
Serum cystatin-C (SCys-C) levels have recently been reported to reflect renal function better than serum creatinine (SCre) levels, and urinary Cys-C (UCys-C) levels have been reported to indicate tubular impairment. We measured the SCys-C and SCre levels of 640 type 2 diabetes patients and found that the SCre levels were elevated in patients with proteinuria who had a decreased glomerular filtration rate (GFR), and the SCys-C levels were significantly elevated in patients with microalbuminuria. Although the UCys-C levels were not correlated with the urinary creatinine (UCre) levels, the UCys-C/UCre ratio (UCCR) tended to be increased in the patients with microalbuminuria, and it was significantly increased in patients with proteinuria and in patients with end-stage renal disease/hemodialysis.<br>These findings suggest that SCys-C and UCys-C determinations are helpful in diagnosing the early stage of diabetic nephropathy and identifying tubular impairment.
Journal
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- Journal of the Japan Diabetes Society
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Journal of the Japan Diabetes Society 51 (6), 489-495, 2008
THE JAPAN DIABETES SOCIETY
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Keywords
Details 詳細情報について
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- CRID
- 1390282679880936192
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- NII Article ID
- 130004511109
- 10021275405
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- NII Book ID
- AN00166576
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- ISSN
- 1881588X
- 0021437X
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- NDL BIB ID
- 9585216
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed