抗GAD抗体陽性C型慢性肝炎に対するインターフェロン療法の検討 Interferon therapy for patients with chronic hepatitis C who are positive for anti-GAD antibody

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著者

    • 塩月 香那子 SHIOTSUKI Kanako
    • 長崎大学医歯薬総合研究科展開医療科学講座第一内科 The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
    • 後藤 貴史 GOTO Takashi
    • 長崎大学医歯薬総合研究科展開医療科学講座第一内科 The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
    • 宮明 寿光 [他] MIYAAKI Hisamitsu
    • 長崎大学医歯薬総合研究科展開医療科学講座第一内科 The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
    • 市川 辰樹 ICHIKAWA Tatsuki
    • 長崎大学医歯薬総合研究科展開医療科学講座第一内科 The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
    • 中尾 一彦 NAKAO Kazuhiko
    • 長崎大学医歯薬総合研究科展開医療科学講座第一内科 The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
    • 江口 勝美 EGUCHI Katsumi
    • 長崎大学医歯薬総合研究科展開医療科学講座第一内科 The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University

抄録

Development of type 1 diabetes mellitus (T1DM) has been reported in patients receiving interferon (IFN) therapy for hepatitis C virus (HCV) infection. We studied two patients with chronic HCV infection who had an anti-glutamic acid decarboxylase antibody (GAD-ab) before IFN therapy. Their blood sugar and GAD-ab levels were monitored during IFN therapy. Case 1 was a 61-year-old man with 16.9 U/mL of GAD-ab. The GAD-ab level decreased during IFN therapy, but remained positive. Case 2 was a 65-year-old woman with 2.0 U/mL of GAD-ab. Her GAD-ab level increased during IFN therapy, but decreased after withdrawal of IFN. Insulin secretion in both patients was kept within physiologically normal range during IFN therapy, and the treatment was completed without developing T1DM in both cases.<br>

収録刊行物

  • 肝臓 = ACTA HEPATOLOGICA JAPONICA  

    肝臓 = ACTA HEPATOLOGICA JAPONICA 49(3), 122-124, 2008-03-25 

    The Japan Society of Hepatology

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各種コード

  • NII論文ID(NAID)
    10021275698
  • NII書誌ID(NCID)
    AN00047770
  • 本文言語コード
    JPN
  • 資料種別
    SHO
  • ISSN
    04514203
  • NDL 記事登録ID
    9432755
  • NDL 雑誌分類
    ZS21(科学技術--医学--内科学)
  • NDL 請求記号
    Z19-130
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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