A RESULT OF INTRA-ARTERIAL LOW-DOSE CISPLATIN COMBINED WITH IRRADIATION AFTER TRANSURETHRAL SURGERY FOR INVASIVE BLADDER CANCER

DOI 59 References

Bibliographic Information

Other Title
  • 浸潤性膀胱癌に対する経尿道的腫瘍切除後の low-dose Cisplatin 動注化学療法併用放射線療法の検討

Search this article

Abstract

Background: The combination of radiotherapy and cisplatin-based chemotherapy has proved to be an effective treatment for bladder carcinoma in many clinical studies. Intra-arterial approaches to chemotherapy have been developed to reduce systemic toxicities and improve response rates. This study was designed to determine the effectiveness of intra-arterial chemotherapy combined with radiotherapy in the treatment of patients with invasive bladder carcinoma. The objectives were to evaluate the response rate, toxicity, and survival rate.<br>Materials and Methods: Twenty-three patients with invasive bladder cancer at clinical stage T2-4 N0-3 M0 who had residual tumor after transurethral resections, were treated with daily intra-arterial cisplatin (5-10 mg/day total, 110-130 mg) and concurrent radiation (2 Gy/day; total, 50-60 Gy). All patients received unilateral or bilateral placement of reservoir to perform daily cisplatin infusion after alteration of intrapelvic blood flow by coil embolizations.<br>Results: A clinical complete response, defined as no viable tumor cell in the biopsy specimen, was observed in 16 (70%) patients, and a partial response was observed in 7 (30%). After a median follow-up of 72 months (range, 25-123 months), 15 patients (65%) were alive. Two cancer-related deaths were observed. Cause-specific and disease-free survival rates at 5 years were 86% and 66%, respectively. Grade3 acute toxic reactions included cystitis in one patient, leukopenia in one, and other forms of toxicity due to chemotherapy, including neuropathy in two patients were tolerable. The regimen was well tolerated, with no severe systemic or local toxicities.<br>Conclusions: The high rates of response and survival observed indicate that this combined intra-arterial chemotherapy and radiotherapy regimen would be useful in the management of invasive bladder carcinoma.

Journal

  • The Journal of JASTRO

    The Journal of JASTRO 18 (4), 225-233, 2006

    Japanese Society for Therapeutic Radiology and Oncology

References(59)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top